SETD1A protects from senescence through regulation of the mitotic gene expression program

SETD1A, a Set1/COMPASS family member maintaining histone-H3-lysine-4 (H3K4) methylation on transcriptionally active promoters, is overexpressed in breast cancer. Here, we show that SETD1A supports mitotic processes and consequentially, its knockdown induces senescence. SETD1A, through promoter H3K4...

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Detalles Bibliográficos
Autores principales: Tajima, Ken, Matsuda, Satoru, Yae, Toshifumi, Drapkin, Benjamin J., Morris, Robert, Boukhali, Myriam, Niederhoffer, Kira, Comaills, Valentine, Dubash, Taronish, Nieman, Linda, Guo, Hongshan, Magnus, Neelima K. C., Dyson, Nick, Shioda, Toshihiro, Haas, Wilhelm, Haber, Daniel A., Maheswaran, Shyamala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599037/
https://www.ncbi.nlm.nih.gov/pubmed/31253781
http://dx.doi.org/10.1038/s41467-019-10786-w

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