Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin

We describe a rare case of autoimmune heparin-induced thrombocytopenia after transcatheter aortic valve implantation in which antibodies against platelet factor 4/heparin have led to platelet activation even after heparin cessation, causing a delayed drop in platelet count to below 20 × 10 (9) /L. M...

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Autores principales: Bakchoul, Tamam, Borst, Oliver, Riessen, Reimer, Lucic, Josip, Gawaz, Meinrad, Althaus, Karina, Aidery, Parwez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Georg Thieme Verlag KG 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599067/
https://www.ncbi.nlm.nih.gov/pubmed/31263800
http://dx.doi.org/10.1055/s-0039-1692990
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author Bakchoul, Tamam
Borst, Oliver
Riessen, Reimer
Lucic, Josip
Gawaz, Meinrad
Althaus, Karina
Aidery, Parwez
author_facet Bakchoul, Tamam
Borst, Oliver
Riessen, Reimer
Lucic, Josip
Gawaz, Meinrad
Althaus, Karina
Aidery, Parwez
author_sort Bakchoul, Tamam
collection PubMed
description We describe a rare case of autoimmune heparin-induced thrombocytopenia after transcatheter aortic valve implantation in which antibodies against platelet factor 4/heparin have led to platelet activation even after heparin cessation, causing a delayed drop in platelet count to below 20 × 10 (9) /L. Most interestingly, platelet count rapidly improved after intravenous immunoglobulin treatment and no new thromboembolic complications were observed with further anticoagulation with rivaroxaban.
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spelling pubmed-65990672019-07-01 Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin Bakchoul, Tamam Borst, Oliver Riessen, Reimer Lucic, Josip Gawaz, Meinrad Althaus, Karina Aidery, Parwez TH Open We describe a rare case of autoimmune heparin-induced thrombocytopenia after transcatheter aortic valve implantation in which antibodies against platelet factor 4/heparin have led to platelet activation even after heparin cessation, causing a delayed drop in platelet count to below 20 × 10 (9) /L. Most interestingly, platelet count rapidly improved after intravenous immunoglobulin treatment and no new thromboembolic complications were observed with further anticoagulation with rivaroxaban. Georg Thieme Verlag KG 2019-06-28 /pmc/articles/PMC6599067/ /pubmed/31263800 http://dx.doi.org/10.1055/s-0039-1692990 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Bakchoul, Tamam
Borst, Oliver
Riessen, Reimer
Lucic, Josip
Gawaz, Meinrad
Althaus, Karina
Aidery, Parwez
Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
title Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
title_full Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
title_fullStr Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
title_full_unstemmed Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
title_short Autoimmune Heparin-Induced Thrombocytopenia after Transcatheter Aortic Valve Implantation: Successful Treatment with Adjunct High-Dose Intravenous Immunoglobulin
title_sort autoimmune heparin-induced thrombocytopenia after transcatheter aortic valve implantation: successful treatment with adjunct high-dose intravenous immunoglobulin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599067/
https://www.ncbi.nlm.nih.gov/pubmed/31263800
http://dx.doi.org/10.1055/s-0039-1692990
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