Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review

Coronary artery disease is one of the most common cardiovascular diseases in the world. Involvement of microRNAs on the pathogenesis of this disease was reported either in beneficial or detrimental way. Different studies have also speculated that circulating microRNAs can be applied as promising bio...

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Autores principales: Melak, Tadele, Baynes, Habtamu Wondifraw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Communications and Publications Division (CPD) of the IFCC 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599194/
https://www.ncbi.nlm.nih.gov/pubmed/31263392
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author Melak, Tadele
Baynes, Habtamu Wondifraw
author_facet Melak, Tadele
Baynes, Habtamu Wondifraw
author_sort Melak, Tadele
collection PubMed
description Coronary artery disease is one of the most common cardiovascular diseases in the world. Involvement of microRNAs on the pathogenesis of this disease was reported either in beneficial or detrimental way. Different studies have also speculated that circulating microRNAs can be applied as promising biomarkers for the diagnosis of coronary artery disease. Particularly, microRNA-133a seems to fulfill the criteria of ideal biomarkers due to its role in the diagnosis, severity assessment and in prognosis. The panel of circulating microRNAs has also improved the predictive power of coronary artery disease compared to single microRNAs. In this review, the role of circulating microRNAs for early detection, severity assessment and prognosis of coronary artery disease were reviewed.
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spelling pubmed-65991942019-07-01 Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review Melak, Tadele Baynes, Habtamu Wondifraw EJIFCC Review Article Coronary artery disease is one of the most common cardiovascular diseases in the world. Involvement of microRNAs on the pathogenesis of this disease was reported either in beneficial or detrimental way. Different studies have also speculated that circulating microRNAs can be applied as promising biomarkers for the diagnosis of coronary artery disease. Particularly, microRNA-133a seems to fulfill the criteria of ideal biomarkers due to its role in the diagnosis, severity assessment and in prognosis. The panel of circulating microRNAs has also improved the predictive power of coronary artery disease compared to single microRNAs. In this review, the role of circulating microRNAs for early detection, severity assessment and prognosis of coronary artery disease were reviewed. The Communications and Publications Division (CPD) of the IFCC 2019-06-24 /pmc/articles/PMC6599194/ /pubmed/31263392 Text en Copyright © 2019 International Federation of Clinical Chemistry and Laboratory Medicine (IFCC). All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Melak, Tadele
Baynes, Habtamu Wondifraw
Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review
title Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review
title_full Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review
title_fullStr Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review
title_full_unstemmed Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review
title_short Circulating microRNAs as possible biomarkers for coronary artery disease: a narrative review
title_sort circulating micrornas as possible biomarkers for coronary artery disease: a narrative review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599194/
https://www.ncbi.nlm.nih.gov/pubmed/31263392
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