Structural basis of TFIIH activation for nucleotide excision repair

Nucleotide excision repair (NER) is the major DNA repair pathway that removes UV-induced and bulky DNA lesions. There is currently no structure of NER intermediates, which form around the large multisubunit transcription factor IIH (TFIIH). Here we report the cryo-EM structure of an NER intermediate...

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Detalles Bibliográficos
Autores principales: Kokic, Goran, Chernev, Aleksandar, Tegunov, Dimitry, Dienemann, Christian, Urlaub, Henning, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599211/
https://www.ncbi.nlm.nih.gov/pubmed/31253769
http://dx.doi.org/10.1038/s41467-019-10745-5

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