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Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana

BACKGROUND: HBV vaccine is known to offer protection against transmission of HBV infection. Health care workers are mandated to have this vaccination as part of their occupational health safety measures. Post vaccination response data for HCWs in our setting is not available. This study therefore ai...

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Autores principales: Obiri-Yeboah, Dorcas, Awuku, Yaw Asante, Adjei, George, Cudjoe, Obed, Benjamin, Anna Hayfron, Obboh, Evans, Amoako-Sakyi, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599216/
https://www.ncbi.nlm.nih.gov/pubmed/31251790
http://dx.doi.org/10.1371/journal.pone.0219148
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author Obiri-Yeboah, Dorcas
Awuku, Yaw Asante
Adjei, George
Cudjoe, Obed
Benjamin, Anna Hayfron
Obboh, Evans
Amoako-Sakyi, Daniel
author_facet Obiri-Yeboah, Dorcas
Awuku, Yaw Asante
Adjei, George
Cudjoe, Obed
Benjamin, Anna Hayfron
Obboh, Evans
Amoako-Sakyi, Daniel
author_sort Obiri-Yeboah, Dorcas
collection PubMed
description BACKGROUND: HBV vaccine is known to offer protection against transmission of HBV infection. Health care workers are mandated to have this vaccination as part of their occupational health safety measures. Post vaccination response data for HCWs in our setting is not available. This study therefore aimed to evaluate the anti-HBs titre levels after Hepatitis B vaccination among HCWs from selected heath facilities in the Cape Coast Metropolis, Ghana. METHODS: A multicenter (3 selected sites) analytical cross-sectional study involving 711 HCWs was conducted. Five (5mls) of blood samples were collected from each study participant and the serum used for HBV immunological profile testing anti-HBs quantification by ELISA test (Fortress Diagnostics Limited, Northern Ireland, United Kingdom). Data analyses were performed using Stata version 14.0 software (STATA Corp, Texas USA). RESULTS: The median age of participants was 29 years (IQR = 26–35 years). Majority (80.9%, n = 575) took their vaccination from Government health facilities compared with 19.1% (n = 136) from private vaccination sources. A total of 7 (3 males and 4 females) were found to be HBsAg positive giving prevalence of 1%. In all, 8.2% (n = 58) of the HCWs had anti-HBs titre levels <10IU/ml giving a sero-protection rate of 91.8%. HCWs who received 3 doses of HBV vaccine were more likely to be sero-protected as compared to those who received only one dose in multivariate analysis (aOR = 3.39, 95%CI: 1.08–10.67), p<0.037). Gender, cigarette smoking and alcohol consumption were not found to be associated with sero-protection. CONCLUSION: There is a high HBV vaccine efficacy among HCWs in the Cape Coast Metropolis of Ghana with higher prevalence of anti-HBs titre level associated with full vaccine dose adherence. Post vaccination antibody titre determination could be an integral part of HBV vaccination protocol for HCWs in Ghana.
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spelling pubmed-65992162019-07-12 Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana Obiri-Yeboah, Dorcas Awuku, Yaw Asante Adjei, George Cudjoe, Obed Benjamin, Anna Hayfron Obboh, Evans Amoako-Sakyi, Daniel PLoS One Research Article BACKGROUND: HBV vaccine is known to offer protection against transmission of HBV infection. Health care workers are mandated to have this vaccination as part of their occupational health safety measures. Post vaccination response data for HCWs in our setting is not available. This study therefore aimed to evaluate the anti-HBs titre levels after Hepatitis B vaccination among HCWs from selected heath facilities in the Cape Coast Metropolis, Ghana. METHODS: A multicenter (3 selected sites) analytical cross-sectional study involving 711 HCWs was conducted. Five (5mls) of blood samples were collected from each study participant and the serum used for HBV immunological profile testing anti-HBs quantification by ELISA test (Fortress Diagnostics Limited, Northern Ireland, United Kingdom). Data analyses were performed using Stata version 14.0 software (STATA Corp, Texas USA). RESULTS: The median age of participants was 29 years (IQR = 26–35 years). Majority (80.9%, n = 575) took their vaccination from Government health facilities compared with 19.1% (n = 136) from private vaccination sources. A total of 7 (3 males and 4 females) were found to be HBsAg positive giving prevalence of 1%. In all, 8.2% (n = 58) of the HCWs had anti-HBs titre levels <10IU/ml giving a sero-protection rate of 91.8%. HCWs who received 3 doses of HBV vaccine were more likely to be sero-protected as compared to those who received only one dose in multivariate analysis (aOR = 3.39, 95%CI: 1.08–10.67), p<0.037). Gender, cigarette smoking and alcohol consumption were not found to be associated with sero-protection. CONCLUSION: There is a high HBV vaccine efficacy among HCWs in the Cape Coast Metropolis of Ghana with higher prevalence of anti-HBs titre level associated with full vaccine dose adherence. Post vaccination antibody titre determination could be an integral part of HBV vaccination protocol for HCWs in Ghana. Public Library of Science 2019-06-28 /pmc/articles/PMC6599216/ /pubmed/31251790 http://dx.doi.org/10.1371/journal.pone.0219148 Text en © 2019 Obiri-Yeboah et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Obiri-Yeboah, Dorcas
Awuku, Yaw Asante
Adjei, George
Cudjoe, Obed
Benjamin, Anna Hayfron
Obboh, Evans
Amoako-Sakyi, Daniel
Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana
title Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana
title_full Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana
title_fullStr Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana
title_full_unstemmed Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana
title_short Post Hepatitis B vaccination sero-conversion among health care workers in the Cape Coast Metropolis of Ghana
title_sort post hepatitis b vaccination sero-conversion among health care workers in the cape coast metropolis of ghana
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599216/
https://www.ncbi.nlm.nih.gov/pubmed/31251790
http://dx.doi.org/10.1371/journal.pone.0219148
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