Development of a new promoter to avoid the silencing of genes in the production of recombinant antibodies in chinese hamster ovary cells

BACKGROUND: The production of recombinant proteins in mammalian cell lines is one of the most important areas in biopharmaceutical industry. Viral transcriptional promoters are widely used to express recombinant proteins in mammalian cell lines. However, these promoters are susceptible to silencing,...

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Detalles Bibliográficos
Autores principales: Zúñiga, Roberto A, Gutiérrez-González, Matías, Collazo, Norberto, Sotelo, Pablo Hérnan, Ribeiro, Carolina H, Altamirano, Claudia, Lorenzo, Carmen, Aguillón, Juan Carlos, Molina, María Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599231/
https://www.ncbi.nlm.nih.gov/pubmed/31297150
http://dx.doi.org/10.1186/s13036-019-0187-y

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