Cargando…

Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs

BACKGROUND: Canine atopic dermatitis (AD) is a common skin disease. The goal of this study was to evaluate food designed to improve skin barrier function and lower inflammation to reduce pruritus and clinical severity in client-owned atopic dogs. The food contained an antioxidant blend to reduce oxi...

Descripción completa

Detalles Bibliográficos
Autores principales: Witzel-Rollins, Angela, Murphy, Maryanne, Becvarova, Iveta, Werre, Stephen R., Cadiergues, Marie-Christine, Meyer, Hein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599232/
https://www.ncbi.nlm.nih.gov/pubmed/31253166
http://dx.doi.org/10.1186/s12917-019-1929-2
_version_ 1783430919718174720
author Witzel-Rollins, Angela
Murphy, Maryanne
Becvarova, Iveta
Werre, Stephen R.
Cadiergues, Marie-Christine
Meyer, Hein
author_facet Witzel-Rollins, Angela
Murphy, Maryanne
Becvarova, Iveta
Werre, Stephen R.
Cadiergues, Marie-Christine
Meyer, Hein
author_sort Witzel-Rollins, Angela
collection PubMed
description BACKGROUND: Canine atopic dermatitis (AD) is a common skin disease. The goal of this study was to evaluate food designed to improve skin barrier function and lower inflammation to reduce pruritus and clinical severity in client-owned atopic dogs. The food contained an antioxidant blend to reduce oxidative stress, plant polyphenols to stabilize mast cells, and polyunsaturated fatty acids to improve skin health and reduce inflammation. RESULTS: Seventeen dogs were included in the analysis. Initially 48 adult atopic dogs were enrolled and exclusively fed a dermatologic food for 8 weeks in a non-controlled, open-label study. Thirty-one dogs were excluded for the following reasons: oral and topical medication changes (n = 17), missing data (n = 4), fatty acid supplementation (n = 3), food refusal (n = 3), dropped out (n = 3), and owner concerns (n = 1). Using a scale from 0 (normal) - 4 (severe), veterinarians evaluated the presence and severity of clinical signs of atopy at weeks 0, 4, and 8. Pet owners also rated their pet’s clinical signs of atopy on a scale from 0 (not present) - 10 (present continuously) at weeks 0, 4, and 8. Compared with initial baseline scores (median 19, range 3–69), the total veterinarian scores were significantly lower at weeks 4 (median 11, range 1–15) and 8 (median 7, range 3–46) (p < 0.05). Similarly, owner assessments showed significant improvements in the least squares mean (LSM) from baseline to 4 weeks (itching, redness, licking, and scratching) continuing to 8 weeks (itching, redness, and scratching) (p < 0.05). CONCLUSIONS: In this open, non-controlled study evaluating a dermatologic diet in seventeen client-owned dogs, owner and veterinarian assessments showed statistically significant reductions in clinical scores designed to measure severity of atopic dermatitis. While these results show promise for the management of canine atopic dermatitis, controlled clinical trials are also needed to affirm our findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-019-1929-2) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6599232
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-65992322019-07-11 Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs Witzel-Rollins, Angela Murphy, Maryanne Becvarova, Iveta Werre, Stephen R. Cadiergues, Marie-Christine Meyer, Hein BMC Vet Res Research Article BACKGROUND: Canine atopic dermatitis (AD) is a common skin disease. The goal of this study was to evaluate food designed to improve skin barrier function and lower inflammation to reduce pruritus and clinical severity in client-owned atopic dogs. The food contained an antioxidant blend to reduce oxidative stress, plant polyphenols to stabilize mast cells, and polyunsaturated fatty acids to improve skin health and reduce inflammation. RESULTS: Seventeen dogs were included in the analysis. Initially 48 adult atopic dogs were enrolled and exclusively fed a dermatologic food for 8 weeks in a non-controlled, open-label study. Thirty-one dogs were excluded for the following reasons: oral and topical medication changes (n = 17), missing data (n = 4), fatty acid supplementation (n = 3), food refusal (n = 3), dropped out (n = 3), and owner concerns (n = 1). Using a scale from 0 (normal) - 4 (severe), veterinarians evaluated the presence and severity of clinical signs of atopy at weeks 0, 4, and 8. Pet owners also rated their pet’s clinical signs of atopy on a scale from 0 (not present) - 10 (present continuously) at weeks 0, 4, and 8. Compared with initial baseline scores (median 19, range 3–69), the total veterinarian scores were significantly lower at weeks 4 (median 11, range 1–15) and 8 (median 7, range 3–46) (p < 0.05). Similarly, owner assessments showed significant improvements in the least squares mean (LSM) from baseline to 4 weeks (itching, redness, licking, and scratching) continuing to 8 weeks (itching, redness, and scratching) (p < 0.05). CONCLUSIONS: In this open, non-controlled study evaluating a dermatologic diet in seventeen client-owned dogs, owner and veterinarian assessments showed statistically significant reductions in clinical scores designed to measure severity of atopic dermatitis. While these results show promise for the management of canine atopic dermatitis, controlled clinical trials are also needed to affirm our findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12917-019-1929-2) contains supplementary material, which is available to authorized users. BioMed Central 2019-06-28 /pmc/articles/PMC6599232/ /pubmed/31253166 http://dx.doi.org/10.1186/s12917-019-1929-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Witzel-Rollins, Angela
Murphy, Maryanne
Becvarova, Iveta
Werre, Stephen R.
Cadiergues, Marie-Christine
Meyer, Hein
Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
title Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
title_full Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
title_fullStr Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
title_full_unstemmed Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
title_short Non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
title_sort non-controlled, open-label clinical trial to assess the effectiveness of a dietetic food on pruritus and dermatologic scoring in atopic dogs
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599232/
https://www.ncbi.nlm.nih.gov/pubmed/31253166
http://dx.doi.org/10.1186/s12917-019-1929-2
work_keys_str_mv AT witzelrollinsangela noncontrolledopenlabelclinicaltrialtoassesstheeffectivenessofadieteticfoodonpruritusanddermatologicscoringinatopicdogs
AT murphymaryanne noncontrolledopenlabelclinicaltrialtoassesstheeffectivenessofadieteticfoodonpruritusanddermatologicscoringinatopicdogs
AT becvarovaiveta noncontrolledopenlabelclinicaltrialtoassesstheeffectivenessofadieteticfoodonpruritusanddermatologicscoringinatopicdogs
AT werrestephenr noncontrolledopenlabelclinicaltrialtoassesstheeffectivenessofadieteticfoodonpruritusanddermatologicscoringinatopicdogs
AT cadierguesmariechristine noncontrolledopenlabelclinicaltrialtoassesstheeffectivenessofadieteticfoodonpruritusanddermatologicscoringinatopicdogs
AT meyerhein noncontrolledopenlabelclinicaltrialtoassesstheeffectivenessofadieteticfoodonpruritusanddermatologicscoringinatopicdogs