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Cardiac tissue engineering: state-of-the-art methods and outlook
The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Those interdisciplinary emerging innovations would move forward basic research in this field an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599291/ https://www.ncbi.nlm.nih.gov/pubmed/31297148 http://dx.doi.org/10.1186/s13036-019-0185-0 |
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author | Nguyen, Anh H. Marsh, Paul Schmiess-Heine, Lauren Burke, Peter J. Lee, Abraham Lee, Juhyun Cao, Hung |
author_facet | Nguyen, Anh H. Marsh, Paul Schmiess-Heine, Lauren Burke, Peter J. Lee, Abraham Lee, Juhyun Cao, Hung |
author_sort | Nguyen, Anh H. |
collection | PubMed |
description | The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Those interdisciplinary emerging innovations would move forward basic research in this field and their clinical applications. The long-entrenched challenges in this field could be addressed by novel 3-dimensional (3D) scaffold substrates for cardiomyocyte (CM) growth and maturation. Stem cell-based therapy through genome editing techniques can repair gene mutation, control better maturation of CMs or even reveal its molecular clock. Finally, machine learning and precision control for improvements of the construct fabrication process and optimization in tissue-specific clonal selections with an outlook of cardiac tissue engineering are also presented. |
format | Online Article Text |
id | pubmed-6599291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65992912019-07-11 Cardiac tissue engineering: state-of-the-art methods and outlook Nguyen, Anh H. Marsh, Paul Schmiess-Heine, Lauren Burke, Peter J. Lee, Abraham Lee, Juhyun Cao, Hung J Biol Eng Review The purpose of this review is to assess the state-of-the-art fabrication methods, advances in genome editing, and the use of machine learning to shape the prospective growth in cardiac tissue engineering. Those interdisciplinary emerging innovations would move forward basic research in this field and their clinical applications. The long-entrenched challenges in this field could be addressed by novel 3-dimensional (3D) scaffold substrates for cardiomyocyte (CM) growth and maturation. Stem cell-based therapy through genome editing techniques can repair gene mutation, control better maturation of CMs or even reveal its molecular clock. Finally, machine learning and precision control for improvements of the construct fabrication process and optimization in tissue-specific clonal selections with an outlook of cardiac tissue engineering are also presented. BioMed Central 2019-06-28 /pmc/articles/PMC6599291/ /pubmed/31297148 http://dx.doi.org/10.1186/s13036-019-0185-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Nguyen, Anh H. Marsh, Paul Schmiess-Heine, Lauren Burke, Peter J. Lee, Abraham Lee, Juhyun Cao, Hung Cardiac tissue engineering: state-of-the-art methods and outlook |
title | Cardiac tissue engineering: state-of-the-art methods and outlook |
title_full | Cardiac tissue engineering: state-of-the-art methods and outlook |
title_fullStr | Cardiac tissue engineering: state-of-the-art methods and outlook |
title_full_unstemmed | Cardiac tissue engineering: state-of-the-art methods and outlook |
title_short | Cardiac tissue engineering: state-of-the-art methods and outlook |
title_sort | cardiac tissue engineering: state-of-the-art methods and outlook |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599291/ https://www.ncbi.nlm.nih.gov/pubmed/31297148 http://dx.doi.org/10.1186/s13036-019-0185-0 |
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