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Spermidine/spermine-N(1)-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

BACKGROUND: Tau stabilizes microtubules; however, in Alzheimer’s disease (AD) and tauopathies, tau becomes hyperphosphorylated, aggregates, and results in neuronal death. Our group recently uncovered a unique interaction between polyamine metabolism and tau fate. Polyamines exert an array of physiol...

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Detalles Bibliográficos
Autores principales:	Sandusky-Beltran, Leslie A., Kovalenko, Andrii, Ma, Chao, Calahatian, John Ivan T., Placides, Devon S., Watler, Mallory D., Hunt, Jerry B., Darling, April L., Baker, Jeremy D., Blair, Laura J., Martin, Mackenzie D., Fontaine, Sarah N., Dickey, Chad A., Lussier, April L., Weeber, Edwin J., Selenica, Maj-Linda B., Nash, Kevin R., Gordon, Marcia N., Morgan, Dave, Lee, Daniel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599347/ https://www.ncbi.nlm.nih.gov/pubmed/31253191 http://dx.doi.org/10.1186/s13195-019-0507-y

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