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Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β

CONTEXT: The two major forms of circulating thyroid hormones (THs) are T3 and T4. T3 is regarded as the biologically active hormone because it binds to TH receptors (TRs) with greater affinity than T4. However, it is currently unclear what structural mechanisms underlie this difference in affinity....

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Detalles Bibliográficos
Autores principales:	Wejaphikul, Karn, Groeneweg, Stefan, Hilhorst-Hofstee, Yvonne, Chatterjee, V Krishna, Peeters, Robin P, Meima, Marcel E, Visser, W Edward
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2019
Materias:	Clinical Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599431/ https://www.ncbi.nlm.nih.gov/pubmed/30817817 http://dx.doi.org/10.1210/jc.2018-02794

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