Alcohol induced IL-17A production in Paneth cells amplifies endoplasmic reticulum stress, apoptosis and inflammasome-IL-18 activation in the proximal small intestine in mice

Gut microbial translocation contributes to alcoholic hepatitis. Using a mouse model of alcoholic hepatitis, we investigated the effects of chronic alcohol plus binge and found increased abundance of Paneth cells and IL-17A in the proximal small intestine (PSI). Alcohol increased IL-17A production an...

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Detalles Bibliográficos
Autores principales: Gyongyosi, B., Cho, Y., Lowe, P., Calenda, C.D., Iracheta-Vellve, A., Satishchandran, A., Ambade, A., Szabo, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599481/
https://www.ncbi.nlm.nih.gov/pubmed/31105269
http://dx.doi.org/10.1038/s41385-019-0170-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599481/
https://www.ncbi.nlm.nih.gov/pubmed/31105269
http://dx.doi.org/10.1038/s41385-019-0170-4

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