Epigenetic suppression of liver X receptor β in anterior cingulate cortex by HDAC5 drives CFA-induced chronic inflammatory pain

BACKGROUND: Liver X receptors (LXRs), including LXRα and LXRβ, are key regulators of transcriptional programs for both cholesterol homeostasis and inflammation in the brain. Here, the modes of action of LXRs and the epigenetic mechanisms regulating LXRβ expression in anterior cingulate cortex (ACC)...

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Detalles Bibliográficos
Autores principales: Li, Yu-Jiao, Zhang, Kun, Sun, Ting, Wang, Jian, Guo, Yan-Yan, Yang, Le, Yang, Qi, Li, Yan-Jiao, Liu, Shui-Bing, Zhao, Ming-Gao, Wu, Yu-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599528/
https://www.ncbi.nlm.nih.gov/pubmed/31255170
http://dx.doi.org/10.1186/s12974-019-1507-3

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