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Nuclear envelope assembly defects link mitotic errors to chromothripsis
Defects in the architecture or integrity of the nuclear envelope (NE) are associated with a variety of human diseases(1). Micronuclei, one common nuclear aberration, are an origin for chromothripsis(2), a catastrophic mutational process commonly observed in cancer(3–5). Chromothripsis occurs after m...
Autores principales: | Liu, Shiwei, Kwon, Mijung, Mannino, Mark, Yang, Nachen, Renda, Fioranna, Khodjakov, Alexey, Pellman, David |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599625/ https://www.ncbi.nlm.nih.gov/pubmed/30232450 http://dx.doi.org/10.1038/s41586-018-0534-z |
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