Dual-responsive, Methotrexate-loaded, Ascorbic acid-derived Micelles Exert Anti-tumor and Anti-metastatic Effects by Inhibiting NF-κB Signaling in an Orthotopic Mouse Model of Human Choriocarcinoma

Gestational trophoblastic neoplasia (GTN), the most aggressive form of which is choriocarcinoma, can result from over-proliferation of trophoblasts. Treating choriocarcinoma requires high doses of systemic chemotherapeutic agents, which result in nonspecific drug distribution and severe toxicity. To...

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Detalles Bibliográficos
Autores principales: Wei, Lili, Wang, Chenyuan, Chen, Xianjue, Yang, Bing, Shi, Kun, Benington, Leah R., Lim, Lee Yong, Shi, Sanjun, Mo, Jingxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599650/
https://www.ncbi.nlm.nih.gov/pubmed/31285766
http://dx.doi.org/10.7150/thno.35125

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