The role of Na(v)1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes

Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic neuropathy. Methods: Scratching behavior,...

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Detalles Bibliográficos
Autores principales: Cheng, Ruo-Xiao, Feng, Yu, Liu, Di, Wang, Zhi-Hong, Zhang, Jiang-Tao, Chen, Li-Hua, Su, Cun-Jin, Wang, Bing, Huang, Ya, Ji, Ru-Rong, Hu, Ji, Liu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599654/
https://www.ncbi.nlm.nih.gov/pubmed/31285762
http://dx.doi.org/10.7150/thno.36077

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