Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma

Although multiple myeloma (MM) had been an incurable hematological malignancy with a poor prognosis, recent advances in novel anti-neoplastic agents, including carfilzomib (a proteasome inhibitor), have improved the prognosis. We herein report two cases of congestive heart failure in patients treate...

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Autores principales: Ikoma, Takenori, Saotome, Masao, Sano, Makoto, Suwa, Kenichiro, Naruse, Yoshihisa, Ohtani, Hayato, Urushida, Tsuyoshi, Nagata, Yasuyuki, Ono, Takaaki, Maekawa, Yuichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599935/
https://www.ncbi.nlm.nih.gov/pubmed/30713316
http://dx.doi.org/10.2169/internalmedicine.2194-18
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author Ikoma, Takenori
Saotome, Masao
Sano, Makoto
Suwa, Kenichiro
Naruse, Yoshihisa
Ohtani, Hayato
Urushida, Tsuyoshi
Nagata, Yasuyuki
Ono, Takaaki
Maekawa, Yuichiro
author_facet Ikoma, Takenori
Saotome, Masao
Sano, Makoto
Suwa, Kenichiro
Naruse, Yoshihisa
Ohtani, Hayato
Urushida, Tsuyoshi
Nagata, Yasuyuki
Ono, Takaaki
Maekawa, Yuichiro
author_sort Ikoma, Takenori
collection PubMed
description Although multiple myeloma (MM) had been an incurable hematological malignancy with a poor prognosis, recent advances in novel anti-neoplastic agents, including carfilzomib (a proteasome inhibitor), have improved the prognosis. We herein report two cases of congestive heart failure in patients treated with carfilzomib. Although there are some reports on the cardiotoxicity of carfilzomib, to our knowledge, this is the first report on the cardiac involvement of carfilzomib in Japanese MM patients. We review the critical points from our two cases, with the aim of avoiding carfilzomib-associated heart failure in MM patients.
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spelling pubmed-65999352019-07-01 Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma Ikoma, Takenori Saotome, Masao Sano, Makoto Suwa, Kenichiro Naruse, Yoshihisa Ohtani, Hayato Urushida, Tsuyoshi Nagata, Yasuyuki Ono, Takaaki Maekawa, Yuichiro Intern Med Case Report Although multiple myeloma (MM) had been an incurable hematological malignancy with a poor prognosis, recent advances in novel anti-neoplastic agents, including carfilzomib (a proteasome inhibitor), have improved the prognosis. We herein report two cases of congestive heart failure in patients treated with carfilzomib. Although there are some reports on the cardiotoxicity of carfilzomib, to our knowledge, this is the first report on the cardiac involvement of carfilzomib in Japanese MM patients. We review the critical points from our two cases, with the aim of avoiding carfilzomib-associated heart failure in MM patients. The Japanese Society of Internal Medicine 2019-02-01 2019-06-01 /pmc/articles/PMC6599935/ /pubmed/30713316 http://dx.doi.org/10.2169/internalmedicine.2194-18 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ikoma, Takenori
Saotome, Masao
Sano, Makoto
Suwa, Kenichiro
Naruse, Yoshihisa
Ohtani, Hayato
Urushida, Tsuyoshi
Nagata, Yasuyuki
Ono, Takaaki
Maekawa, Yuichiro
Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
title Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
title_full Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
title_fullStr Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
title_full_unstemmed Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
title_short Cardiotoxicity of Carfilzomib in Two Japanese Patients with Relapsed Multiple Myeloma
title_sort cardiotoxicity of carfilzomib in two japanese patients with relapsed multiple myeloma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599935/
https://www.ncbi.nlm.nih.gov/pubmed/30713316
http://dx.doi.org/10.2169/internalmedicine.2194-18
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