Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes

We report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Guérin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer re...

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Autores principales: Fujiu, Koichi, Fukaya, Yasuo, Kamimoto, Masahiro, Miyamoto, Hideaki, Cong, Yue, Suzuki, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600031/
https://www.ncbi.nlm.nih.gov/pubmed/31275133
http://dx.doi.org/10.1159/000500978
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author Fujiu, Koichi
Fukaya, Yasuo
Kamimoto, Masahiro
Miyamoto, Hideaki
Cong, Yue
Suzuki, Hiroyuki
author_facet Fujiu, Koichi
Fukaya, Yasuo
Kamimoto, Masahiro
Miyamoto, Hideaki
Cong, Yue
Suzuki, Hiroyuki
author_sort Fujiu, Koichi
collection PubMed
description We report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Guérin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer recurrence. She was started on nivolumab treatment, and complete response was achieved for one year. However, during this time, she was diagnosed with superficial bladder cancer and underwent surgery but experienced recurrence. After one month of intravesical BCG instillation, the patient developed acute-onset type 1 diabetes. Thus, we recommend that combined application of nivolumab and intravesical BCG be avoided.
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spelling pubmed-66000312019-07-03 Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes Fujiu, Koichi Fukaya, Yasuo Kamimoto, Masahiro Miyamoto, Hideaki Cong, Yue Suzuki, Hiroyuki Case Rep Oncol Case Report We report a case of acute-onset type 1 diabetes due to combined application of nivolumab and intravesical Bacillus Calmette-Guérin (BCG). An 84-year-old woman underwent lung resection for pulmonary squamous cell carcinoma. She had been treated for type 2 diabetes and later experienced lung cancer recurrence. She was started on nivolumab treatment, and complete response was achieved for one year. However, during this time, she was diagnosed with superficial bladder cancer and underwent surgery but experienced recurrence. After one month of intravesical BCG instillation, the patient developed acute-onset type 1 diabetes. Thus, we recommend that combined application of nivolumab and intravesical BCG be avoided. S. Karger AG 2019-06-13 /pmc/articles/PMC6600031/ /pubmed/31275133 http://dx.doi.org/10.1159/000500978 Text en Copyright © 2019 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Fujiu, Koichi
Fukaya, Yasuo
Kamimoto, Masahiro
Miyamoto, Hideaki
Cong, Yue
Suzuki, Hiroyuki
Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
title Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
title_full Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
title_fullStr Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
title_full_unstemmed Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
title_short Combined Application of Nivolumab and Intravesical Bacillus Calmette-Guérin Led to Acute-Onset Type 1 Diabetes
title_sort combined application of nivolumab and intravesical bacillus calmette-guérin led to acute-onset type 1 diabetes
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600031/
https://www.ncbi.nlm.nih.gov/pubmed/31275133
http://dx.doi.org/10.1159/000500978
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