Cargando…

CAIX Regulates Invadopodia Formation through Both a pH-Dependent Mechanism and Interplay with Actin Regulatory Proteins

Tumor metastasis is tightly linked with invasive membrane protrusions, invadopodia, formed by actively invading tumor cells. Hypoxia and pH modulation play a role in the invadopodia formation and in their matrix degradation ability. Tumor-associated carbonic anhydrase IX (CAIX), induced by hypoxia,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Debreova, Michaela, Csaderova, Lucia, Burikova, Monika, Lukacikova, Lubomira, Kajanova, Ivana, Sedlakova, Olga, Kery, Martin, Kopacek, Juraj, Zatovicova, Miriam, Bizik, Jozef, Pastorekova, Silvia, Svastova, Eliska
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600150/ https://www.ncbi.nlm.nih.gov/pubmed/31167468 http://dx.doi.org/10.3390/ijms20112745

Ejemplares similares

Impairment of carbonic anhydrase IX ectodomain cleavage reinforces tumorigenic and metastatic phenotype of cancer cells
por: Kajanova, Ivana, et al.
Publicado: (2020)

Carbonic Anhydrase IX—Mouse versus Human
por: Takacova, Martina, et al.
Publicado: (2019)

The effect of carbonic anhydrase IX on focal contacts during cell spreading and migration
por: Csaderova, Lucia, et al.
Publicado: (2013)

Clinical and Pre-Clinical Evidence of Carbonic Anhydrase IX in Pancreatic Cancer and Its High Expression in Pre-Cancerous Lesions
por: Strapcova, Sabina, et al.
Publicado: (2020)

Lactate stimulates CA IX expression in normoxic cancer cells
por: Panisova, Elena, et al.
Publicado: (2017)

Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors
por: Sedlakova, Olga, et al.
Publicado: (2014)

Novel humanized monoclonal antibodies for targeting hypoxic human tumors via two distinct extracellular domains of carbonic anhydrase IX
por: Zatovicova, Miriam, et al.
Publicado: (2022)

PIMT Binding to C-Terminal Ala459 of CAIX Is Involved in Inside-Out Signaling Necessary for Its Catalytic Activity
por: Simko, Veronika, et al.
Publicado: (2020)

ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non-redundantly to ADAM17
por: Zatovicova, Miriam, et al.
Publicado: (2022)

CAIX-Mediated Control of LIN28/let-7 Axis Contributes to Metabolic Adaptation of Breast Cancer Cells to Hypoxia
por: Gibadulinova, Adriana, et al.
Publicado: (2020)

Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17
por: Zatovicova, M, et al.
Publicado: (2005)

CA IX Stabilizes Intracellular pH to Maintain Metabolic Reprogramming and Proliferation in Hypoxia
por: Benej, Martin, et al.
Publicado: (2020)

Understanding metabolic alterations and heterogeneity in cancer progression through validated immunodetection of key molecular components: a case of carbonic anhydrase IX
por: Takacova, Martina, et al.
Publicado: (2022)

Sulforaphane-induced apoptosis involves the type 1 IP(3) receptor
por: Hudecova, Sona, et al.
Publicado: (2016)

Detection of Breast Cancer Cells Using Acoustics Aptasensor Specific to HER2 Receptors
por: Poturnayová, Alexandra, et al.
Publicado: (2019)

Dexamethasone downregulates expression of carbonic anhydrase IX via HIF-1α and NF-κB-dependent mechanisms
por: Simko, Veronika, et al.
Publicado: (2016)

Apoptosis-induced ectodomain shedding of hypoxia-regulated carbonic anhydrase IX from tumor cells: a double-edged response to chemotherapy
por: Vidlickova, Ivana, et al.
Publicado: (2016)

Mechanical interplay between invadopodia and the nucleus in cultured cancer cells
por: Revach, Or-Yam, et al.
Publicado: (2015)

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia
por: Schoumacher, Marie, et al.
Publicado: (2010)

Carnosine inhibits carbonic anhydrase IX-mediated extracellular acidosis and suppresses growth of HeLa tumor xenografts
por: Ditte, Zuzana, et al.
Publicado: (2014)

Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2
por: Ohradanova, A, et al.
Publicado: (2008)

A Multifunctional Graphene Oxide Platform for Targeting Cancer
por: Bugárová, Nikola, et al.
Publicado: (2019)

Invadopodia in context
por: Bergman, Aviv, et al.
Publicado: (2014)

Selective Tumor Hypoxia Targeting Using M75 Antibody Conjugated Photothermally Active MoO(x) Nanoparticles
por: Annušová, Adriana, et al.
Publicado: (2023)

Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype
por: Barathova, M, et al.
Publicado: (2008)

Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models
por: Bullova, Petra, et al.
Publicado: (2016)

Cortactin function in invadopodia
por: Jeannot, Pauline, et al.
Publicado: (2017)

DNA Methylation Mediates EMT Gene Expression in Human Pancreatic Ductal Adenocarcinoma Cell Lines
por: Urbanova, Maria, et al.
Publicado: (2022)

Carbonic Anhydrase IX (CAIX), Cancer, and Radiation Responsiveness
por: Ward, Carol, et al.
Publicado: (2018)

Expression of transmembrane carbonic anhydrases, CAIX and CAXII, in human development
por: Liao, Shu-Yuan, et al.
Publicado: (2009)

The Expression of Glut-1, CAIX, and MCT4 in Mucinous Carcinoma
por: Kim, Sewha, et al.
Publicado: (2013)

CARMIL2 is a novel molecular connection between vimentin and actin essential for cell migration and invadopodia formation
por: Lanier, M. Hunter, et al.
Publicado: (2015)

MARCKSL1 interacted with F‐actin to promote esophageal squamous cell carcinoma mobility by modulating the formation of invadopodia
por: Zhao, Yue, et al.
Publicado: (2022)

Investigation of the Prognostic Role of Carbonic Anhydrase 9 (CAIX) of the Cellular mRNA/Protein Level or Soluble CAIX Protein in Patients with Oral Squamous Cell Carcinoma
por: Eckert, Alexander W., et al.
Publicado: (2019)

Dense collagen kindles invadopodia formation
por: Short, Ben
Publicado: (2015)

Podosome-like structures of non-invasive carcinoma cells are replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia
por: Takkunen, Minna, et al.
Publicado: (2010)

Podosome-like structures of non-invasive carcinoma cellsare replaced in epithelial-mesenchymal transition by actin comet-embedded invadopodia
por: Takkunen, Minna, et al.
Publicado: (2010)

CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis
por: Hoffmann, Céline, et al.
Publicado: (2016)

The Sulfamate Small Molecule CAIX Inhibitor S4 Modulates Doxorubicin Efficacy
por: van Kuijk, Simon J. A., et al.
Publicado: (2016)

CAIX-targeting radiotracers for hypoxia imaging in head and neck cancer models
por: Huizing, Fokko J., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_245nsa9c206g8fekpu3mqdrgn0