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E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease
E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues. The colon or large intestine is lined by an epithelial monolayer that...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600153/ https://www.ncbi.nlm.nih.gov/pubmed/31195621 http://dx.doi.org/10.3390/ijms20112756 |
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author | Daulagala, Amanda C. Bridges, Mary Catherine Kourtidis, Antonis |
author_facet | Daulagala, Amanda C. Bridges, Mary Catherine Kourtidis, Antonis |
author_sort | Daulagala, Amanda C. |
collection | PubMed |
description | E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues. The colon or large intestine is lined by an epithelial monolayer that encompasses an E-cadherin-dependent barrier, critical for the homeostasis of the organ. Compromised barriers of the colonic epithelium lead to inflammation, fibrosis, and are commonly observed in colorectal cancer. In addition to its architectural role, E-cadherin is also considered a tumor suppressor in the colon, primarily a result of its opposing function to Wnt signaling, the predominant driver of colon tumorigenesis. Beyond these well-established traditional roles, several studies have portrayed an evolving role of E-cadherin as a signaling epicenter that regulates cell behavior in response to intra- and extra-cellular cues. Intriguingly, these recent findings also reveal tumor-promoting functions of E-cadherin in colon tumorigenesis and new interacting partners, opening future avenues of investigation. In this Review, we focus on these emerging aspects of E-cadherin signaling, and we discuss their implications in colon biology and disease. |
format | Online Article Text |
id | pubmed-6600153 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-66001532019-07-16 E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease Daulagala, Amanda C. Bridges, Mary Catherine Kourtidis, Antonis Int J Mol Sci Review E-cadherin is the core component of epithelial adherens junctions, essential for tissue development, differentiation, and maintenance. It is also fundamental for tissue barrier formation, a critical function of epithelial tissues. The colon or large intestine is lined by an epithelial monolayer that encompasses an E-cadherin-dependent barrier, critical for the homeostasis of the organ. Compromised barriers of the colonic epithelium lead to inflammation, fibrosis, and are commonly observed in colorectal cancer. In addition to its architectural role, E-cadherin is also considered a tumor suppressor in the colon, primarily a result of its opposing function to Wnt signaling, the predominant driver of colon tumorigenesis. Beyond these well-established traditional roles, several studies have portrayed an evolving role of E-cadherin as a signaling epicenter that regulates cell behavior in response to intra- and extra-cellular cues. Intriguingly, these recent findings also reveal tumor-promoting functions of E-cadherin in colon tumorigenesis and new interacting partners, opening future avenues of investigation. In this Review, we focus on these emerging aspects of E-cadherin signaling, and we discuss their implications in colon biology and disease. MDPI 2019-06-05 /pmc/articles/PMC6600153/ /pubmed/31195621 http://dx.doi.org/10.3390/ijms20112756 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Daulagala, Amanda C. Bridges, Mary Catherine Kourtidis, Antonis E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease |
title | E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease |
title_full | E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease |
title_fullStr | E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease |
title_full_unstemmed | E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease |
title_short | E-cadherin Beyond Structure: A Signaling Hub in Colon Homeostasis and Disease |
title_sort | e-cadherin beyond structure: a signaling hub in colon homeostasis and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600153/ https://www.ncbi.nlm.nih.gov/pubmed/31195621 http://dx.doi.org/10.3390/ijms20112756 |
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