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Attenuation of Infectious Bronchitis Virus in Eggs Results in Different Patterns of Genomic Variation across Multiple Replicates

The gammacoronavirus infectious bronchitis virus (IBV) causes an acute, highly contagious respiratory disease of poultry. Live attenuated vaccines are traditionally generated by serial passage of a virulent strain in embryonated chicken eggs; however, the molecular mechanism of attenuation is unknow...

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Detalles Bibliográficos
Autores principales:	Oade, Michael S., Keep, Sarah, Freimanis, Graham L., Orton, Richard J., Britton, Paul, Hammond, John A., Bickerton, Erica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Genetic Diversity and Evolution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600199/ https://www.ncbi.nlm.nih.gov/pubmed/31043525 http://dx.doi.org/10.1128/JVI.00492-19

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