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New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate

New polymeric films with antibacterial activity have been prepared, by simple UV-induced copolymerization of readily available ω-(acryloyloxy)-N,N,N-triethylalcan-1-aminium bromides (or acryloyloxyalkyltriethylammonium bromides, AATEABs) with commercially available 2-hydroxyethyl methacrylate (HEMA)...

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Autores principales: Galiano, Francesco, Mancuso, Raffaella, Guzzo, Maria Grazia, Lucente, Fabrizio, Gukelberger, Ephraim, Losso, Maria Adele, Figoli, Alberto, Hoinkis, Jan, Gabriele, Bartolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600214/
https://www.ncbi.nlm.nih.gov/pubmed/31159299
http://dx.doi.org/10.3390/ijms20112696
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author Galiano, Francesco
Mancuso, Raffaella
Guzzo, Maria Grazia
Lucente, Fabrizio
Gukelberger, Ephraim
Losso, Maria Adele
Figoli, Alberto
Hoinkis, Jan
Gabriele, Bartolo
author_facet Galiano, Francesco
Mancuso, Raffaella
Guzzo, Maria Grazia
Lucente, Fabrizio
Gukelberger, Ephraim
Losso, Maria Adele
Figoli, Alberto
Hoinkis, Jan
Gabriele, Bartolo
author_sort Galiano, Francesco
collection PubMed
description New polymeric films with antibacterial activity have been prepared, by simple UV-induced copolymerization of readily available ω-(acryloyloxy)-N,N,N-triethylalcan-1-aminium bromides (or acryloyloxyalkyltriethylammonium bromides, AATEABs) with commercially available 2-hydroxyethyl methacrylate (HEMA), at different relative amounts. In particular, the antibacterial activity of polymeric films derived from 11-(acryloyloxy)-N,N,N-triethylundecan-1-aminium bromide (or acryloyloxyundecyltriethylammonium bromide, AUTEAB; bearing a C-11 alkyl chain linker between the acrylate polymerization function and the quaternary ammonium moiety) and 12-(acryloyloxy)-N,N,N-triethyldodecan-1-aminium bromide (or acryloyloxydodecyltriethylammonium bromide, ADTEB, bearing a C-12 alkyl chain linker) has been assessed against Gram-negative Escherichia Coli and Gram-positive Staphylococcus aureus cells. The results obtained have shown a clear concentration-dependent activity against both bacterial strains, the films obtained from homopolymerization of pure AUTEAB and ADTEAB being the most effective. Moreover, ADTEAB-based films showed a higher antibacterial activity with respect to the AUTEAB-based ones. Interestingly, however, both types of films presented a significant activity not only toward Gram-positive S. aureus, but also toward Gram-negative E. Coli cells.
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spelling pubmed-66002142019-07-16 New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate Galiano, Francesco Mancuso, Raffaella Guzzo, Maria Grazia Lucente, Fabrizio Gukelberger, Ephraim Losso, Maria Adele Figoli, Alberto Hoinkis, Jan Gabriele, Bartolo Int J Mol Sci Article New polymeric films with antibacterial activity have been prepared, by simple UV-induced copolymerization of readily available ω-(acryloyloxy)-N,N,N-triethylalcan-1-aminium bromides (or acryloyloxyalkyltriethylammonium bromides, AATEABs) with commercially available 2-hydroxyethyl methacrylate (HEMA), at different relative amounts. In particular, the antibacterial activity of polymeric films derived from 11-(acryloyloxy)-N,N,N-triethylundecan-1-aminium bromide (or acryloyloxyundecyltriethylammonium bromide, AUTEAB; bearing a C-11 alkyl chain linker between the acrylate polymerization function and the quaternary ammonium moiety) and 12-(acryloyloxy)-N,N,N-triethyldodecan-1-aminium bromide (or acryloyloxydodecyltriethylammonium bromide, ADTEB, bearing a C-12 alkyl chain linker) has been assessed against Gram-negative Escherichia Coli and Gram-positive Staphylococcus aureus cells. The results obtained have shown a clear concentration-dependent activity against both bacterial strains, the films obtained from homopolymerization of pure AUTEAB and ADTEAB being the most effective. Moreover, ADTEAB-based films showed a higher antibacterial activity with respect to the AUTEAB-based ones. Interestingly, however, both types of films presented a significant activity not only toward Gram-positive S. aureus, but also toward Gram-negative E. Coli cells. MDPI 2019-05-31 /pmc/articles/PMC6600214/ /pubmed/31159299 http://dx.doi.org/10.3390/ijms20112696 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Galiano, Francesco
Mancuso, Raffaella
Guzzo, Maria Grazia
Lucente, Fabrizio
Gukelberger, Ephraim
Losso, Maria Adele
Figoli, Alberto
Hoinkis, Jan
Gabriele, Bartolo
New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate
title New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate
title_full New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate
title_fullStr New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate
title_full_unstemmed New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate
title_short New Polymeric Films with Antibacterial Activity Obtained by UV-induced Copolymerization of Acryloyloxyalkyltriethylammonium Salts with 2-Hydroxyethyl Methacrylate
title_sort new polymeric films with antibacterial activity obtained by uv-induced copolymerization of acryloyloxyalkyltriethylammonium salts with 2-hydroxyethyl methacrylate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600214/
https://www.ncbi.nlm.nih.gov/pubmed/31159299
http://dx.doi.org/10.3390/ijms20112696
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