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p63 at the Crossroads between Stemness and Metastasis in Breast Cancer

After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among women, worldwide. Although advances in screening approaches and targeted therapeutic agents have decreased BC incidence and mortality, over the past five years, triple-negative breast cancer (TNBC) remains the bre...

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Autores principales: Gatti, Veronica, Bongiorno-Borbone, Lucilla, Fierro, Claudia, Annicchiarico-Petruzzelli, Margherita, Melino, Gerry, Peschiaroli, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600246/
https://www.ncbi.nlm.nih.gov/pubmed/31159154
http://dx.doi.org/10.3390/ijms20112683
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author Gatti, Veronica
Bongiorno-Borbone, Lucilla
Fierro, Claudia
Annicchiarico-Petruzzelli, Margherita
Melino, Gerry
Peschiaroli, Angelo
author_facet Gatti, Veronica
Bongiorno-Borbone, Lucilla
Fierro, Claudia
Annicchiarico-Petruzzelli, Margherita
Melino, Gerry
Peschiaroli, Angelo
author_sort Gatti, Veronica
collection PubMed
description After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among women, worldwide. Although advances in screening approaches and targeted therapeutic agents have decreased BC incidence and mortality, over the past five years, triple-negative breast cancer (TNBC) remains the breast cancer subtype that displays the worst prognosis, mainly due to the lack of clinically actionable targets. Genetic and molecular profiling has unveiled the high intrinsic heterogeneity of TNBC, with the basal-like molecular subtypes representing the most diffuse TNBC subtypes, characterized by the expression of basal epithelial markers, such as the transcription factor p63. In this review, we will provide a broad picture on the physiological role of p63, in maintaining the basal epithelial identity, as well as its involvement in breast cancer progression, emphasizing its relevance in tumor cell invasion and stemness.
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spelling pubmed-66002462019-07-16 p63 at the Crossroads between Stemness and Metastasis in Breast Cancer Gatti, Veronica Bongiorno-Borbone, Lucilla Fierro, Claudia Annicchiarico-Petruzzelli, Margherita Melino, Gerry Peschiaroli, Angelo Int J Mol Sci Review After lung cancer, breast cancer (BC) is the most frequent cause of cancer death among women, worldwide. Although advances in screening approaches and targeted therapeutic agents have decreased BC incidence and mortality, over the past five years, triple-negative breast cancer (TNBC) remains the breast cancer subtype that displays the worst prognosis, mainly due to the lack of clinically actionable targets. Genetic and molecular profiling has unveiled the high intrinsic heterogeneity of TNBC, with the basal-like molecular subtypes representing the most diffuse TNBC subtypes, characterized by the expression of basal epithelial markers, such as the transcription factor p63. In this review, we will provide a broad picture on the physiological role of p63, in maintaining the basal epithelial identity, as well as its involvement in breast cancer progression, emphasizing its relevance in tumor cell invasion and stemness. MDPI 2019-05-31 /pmc/articles/PMC6600246/ /pubmed/31159154 http://dx.doi.org/10.3390/ijms20112683 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gatti, Veronica
Bongiorno-Borbone, Lucilla
Fierro, Claudia
Annicchiarico-Petruzzelli, Margherita
Melino, Gerry
Peschiaroli, Angelo
p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
title p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
title_full p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
title_fullStr p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
title_full_unstemmed p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
title_short p63 at the Crossroads between Stemness and Metastasis in Breast Cancer
title_sort p63 at the crossroads between stemness and metastasis in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600246/
https://www.ncbi.nlm.nih.gov/pubmed/31159154
http://dx.doi.org/10.3390/ijms20112683
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