Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds

Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates...

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Autores principales: Koleva, Ana I., Petkova-Yankova, Nevena I., Nikolova, Rositca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600311/
https://www.ncbi.nlm.nih.gov/pubmed/31141889
http://dx.doi.org/10.3390/molecules24112030
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author Koleva, Ana I.
Petkova-Yankova, Nevena I.
Nikolova, Rositca D.
author_facet Koleva, Ana I.
Petkova-Yankova, Nevena I.
Nikolova, Rositca D.
author_sort Koleva, Ana I.
collection PubMed
description Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates and alkyl 1,2-benzoxaphosphorin-3-carboxylates. Their chemical properties as acceptors in conjugate addition reactions, [2+2] and [3+2] cycloaddition reactions are discussed.
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spelling pubmed-66003112019-07-16 Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds Koleva, Ana I. Petkova-Yankova, Nevena I. Nikolova, Rositca D. Molecules Review Coumarins are an important class of natural heterocyclic compounds that have attracted considerable synthetic and pharmacological interest due to their various biological activities. This review emphasizes on the synthetic methods for the preparation of dialkyl 2-oxo-2H-1-benzo- pyran-3-phosphonates and alkyl 1,2-benzoxaphosphorin-3-carboxylates. Their chemical properties as acceptors in conjugate addition reactions, [2+2] and [3+2] cycloaddition reactions are discussed. MDPI 2019-05-28 /pmc/articles/PMC6600311/ /pubmed/31141889 http://dx.doi.org/10.3390/molecules24112030 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koleva, Ana I.
Petkova-Yankova, Nevena I.
Nikolova, Rositca D.
Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
title Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
title_full Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
title_fullStr Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
title_full_unstemmed Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
title_short Synthesis and Chemical Properties of 3-Phosphono-coumarins and 1,2-Benzoxaphosphorins as Precursors for Bioactive Compounds
title_sort synthesis and chemical properties of 3-phosphono-coumarins and 1,2-benzoxaphosphorins as precursors for bioactive compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600311/
https://www.ncbi.nlm.nih.gov/pubmed/31141889
http://dx.doi.org/10.3390/molecules24112030
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