Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors

We report on new Zn–Salen oligomer receptors able to recognize a nerve agent simulant, namely dimethyl methylphosphonate (DMMP), by a supramolecular approach. In particular, three Zn-Salen oligomers (Zn–Oligo–A, –B, and –C), differing by the length distribution, were obtained and characterized by NM...

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Autores principales: Puglisi, Roberta, Mineo, Placido G., Pappalardo, Andrea, Gulino, Antonino, Trusso Sfrazzetto, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600340/
https://www.ncbi.nlm.nih.gov/pubmed/31181723
http://dx.doi.org/10.3390/molecules24112160
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author Puglisi, Roberta
Mineo, Placido G.
Pappalardo, Andrea
Gulino, Antonino
Trusso Sfrazzetto, Giuseppe
author_facet Puglisi, Roberta
Mineo, Placido G.
Pappalardo, Andrea
Gulino, Antonino
Trusso Sfrazzetto, Giuseppe
author_sort Puglisi, Roberta
collection PubMed
description We report on new Zn–Salen oligomer receptors able to recognize a nerve agent simulant, namely dimethyl methylphosphonate (DMMP), by a supramolecular approach. In particular, three Zn-Salen oligomers (Zn–Oligo–A, –B, and –C), differing by the length distribution, were obtained and characterized by NMR, Gel Permeation Chromatography (GPC), UV-Vis, and fluorescence spectroscopy. Furthermore, we investigated their recognition properties towards DMMP by using fluorescence measurements. We found that the recognition ability depends on the length of the oligomeric chain, and the Zn–Oligo–C shows a binding constant value higher than those already reported in literature for the DMMP detection.
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spelling pubmed-66003402019-07-16 Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors Puglisi, Roberta Mineo, Placido G. Pappalardo, Andrea Gulino, Antonino Trusso Sfrazzetto, Giuseppe Molecules Article We report on new Zn–Salen oligomer receptors able to recognize a nerve agent simulant, namely dimethyl methylphosphonate (DMMP), by a supramolecular approach. In particular, three Zn-Salen oligomers (Zn–Oligo–A, –B, and –C), differing by the length distribution, were obtained and characterized by NMR, Gel Permeation Chromatography (GPC), UV-Vis, and fluorescence spectroscopy. Furthermore, we investigated their recognition properties towards DMMP by using fluorescence measurements. We found that the recognition ability depends on the length of the oligomeric chain, and the Zn–Oligo–C shows a binding constant value higher than those already reported in literature for the DMMP detection. MDPI 2019-06-08 /pmc/articles/PMC6600340/ /pubmed/31181723 http://dx.doi.org/10.3390/molecules24112160 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Puglisi, Roberta
Mineo, Placido G.
Pappalardo, Andrea
Gulino, Antonino
Trusso Sfrazzetto, Giuseppe
Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors
title Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors
title_full Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors
title_fullStr Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors
title_full_unstemmed Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors
title_short Supramolecular Detection of a Nerve Agent Simulant by Fluorescent Zn–Salen Oligomer Receptors
title_sort supramolecular detection of a nerve agent simulant by fluorescent zn–salen oligomer receptors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600340/
https://www.ncbi.nlm.nih.gov/pubmed/31181723
http://dx.doi.org/10.3390/molecules24112160
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