Esculetin, a Coumarin Derivative, Prevents Thrombosis: Inhibitory Signaling on PLCγ2–PKC–AKT Activation in Human Platelets

Esculetin, a bioactive 6,7-dihydroxy derivative of coumarin, possesses pharmacological activities against obesity, diabetes, renal failure, and cardiovascular disorders (CVDs). Platelet activation plays a major role in CVDs. Thus, disrupting platelet activation represents an attractive therapeutic t...

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Detalles Bibliográficos
Autores principales: Hsia, Chih-Wei, Lin, Kao-Chang, Lee, Tzu-Yin, Hsia, Chih-Hsuan, Chou, Duen-Suey, Jayakumar, Thanasekaran, Velusamy, Marappan, Chang, Chao-Chien, Sheu, Joen-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600380/
https://www.ncbi.nlm.nih.gov/pubmed/31163690
http://dx.doi.org/10.3390/ijms20112731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600380/
https://www.ncbi.nlm.nih.gov/pubmed/31163690
http://dx.doi.org/10.3390/ijms20112731

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