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p53 Binds Preferentially to Non-B DNA Structures Formed by the Pyrimidine-Rich Strands of GAA·TTC Trinucleotide Repeats Associated with Friedreich’s Ataxia

Expansions of trinucleotide repeats (TNRs) are associated with genetic disorders such as Friedreich’s ataxia. The tumor suppressor p53 is a central regulator of cell fate in response to different types of insults. Sequence and structure-selective modes of DNA recognition are among the main attribute...

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Detalles Bibliográficos
Autores principales:	Helma, Robert, Bažantová, Pavla, Petr, Marek, Adámik, Matej, Renčiuk, Daniel, Tichý, Vlastimil, Pastuchová, Alena, Soldánová, Zuzana, Pečinka, Petr, Bowater, Richard P., Fojta, Miroslav, Brázdová, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600395/ https://www.ncbi.nlm.nih.gov/pubmed/31159174 http://dx.doi.org/10.3390/molecules24112078

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