The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities

Recently, the methylene-cycloakylacetate (MCA) scaffold has been reported as a potential pharmacophore for neurite outgrowth activity. In this work, natural diterpenes that embed MCA fragments are reviewed, as they are major components of Halimium viscosum: ent-halimic acid, the prototype for these...

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Autores principales: Tobal, Ignacio E., Roncero, Alejandro M., Moro, Rosalina F., Díez, David, Marcos, Isidro S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600407/
https://www.ncbi.nlm.nih.gov/pubmed/31195609
http://dx.doi.org/10.3390/molecules24112120
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author Tobal, Ignacio E.
Roncero, Alejandro M.
Moro, Rosalina F.
Díez, David
Marcos, Isidro S.
author_facet Tobal, Ignacio E.
Roncero, Alejandro M.
Moro, Rosalina F.
Díez, David
Marcos, Isidro S.
author_sort Tobal, Ignacio E.
collection PubMed
description Recently, the methylene-cycloakylacetate (MCA) scaffold has been reported as a potential pharmacophore for neurite outgrowth activity. In this work, natural diterpenes that embed MCA fragments are reviewed, as they are major components of Halimium viscosum: ent-halimic acid, the prototype for these bioactive compounds. Herein, structures, sources, and activities for the natural diterpenes, as well as their synthetic derivatives of interest, are reviewed.
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spelling pubmed-66004072019-07-16 The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities Tobal, Ignacio E. Roncero, Alejandro M. Moro, Rosalina F. Díez, David Marcos, Isidro S. Molecules Review Recently, the methylene-cycloakylacetate (MCA) scaffold has been reported as a potential pharmacophore for neurite outgrowth activity. In this work, natural diterpenes that embed MCA fragments are reviewed, as they are major components of Halimium viscosum: ent-halimic acid, the prototype for these bioactive compounds. Herein, structures, sources, and activities for the natural diterpenes, as well as their synthetic derivatives of interest, are reviewed. MDPI 2019-06-05 /pmc/articles/PMC6600407/ /pubmed/31195609 http://dx.doi.org/10.3390/molecules24112120 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tobal, Ignacio E.
Roncero, Alejandro M.
Moro, Rosalina F.
Díez, David
Marcos, Isidro S.
The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
title The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
title_full The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
title_fullStr The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
title_full_unstemmed The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
title_short The Methylene-Cycloalkylacetate (MCA) Scaffold in Terpenyl Compounds with Potential Pharmacological Activities
title_sort methylene-cycloalkylacetate (mca) scaffold in terpenyl compounds with potential pharmacological activities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600407/
https://www.ncbi.nlm.nih.gov/pubmed/31195609
http://dx.doi.org/10.3390/molecules24112120
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