Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells

Tumor suppressor p53 is mutated in about 50% of cancers. Most malignant melanomas carry wild-type p53, but p53 activity is often inhibited due to overexpression of its negative regulators Mdm2 or MdmX. We performed high throughput screening of 2448 compounds on A375 cells carrying p53 activity lucif...

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Detalles Bibliográficos
Autores principales: Mrkvová, Zuzana, Uldrijan, Stjepan, Pombinho, Antonio, Bartůněk, Petr, Slaninová, Iva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600429/
https://www.ncbi.nlm.nih.gov/pubmed/31181622
http://dx.doi.org/10.3390/molecules24112152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600429/
https://www.ncbi.nlm.nih.gov/pubmed/31181622
http://dx.doi.org/10.3390/molecules24112152

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