Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity

Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepi...

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Autores principales: Wang, Ning, Świtalska, Marta, Wang, Li, Shaban, Elkhabiry, Hossain, Md Imran, El Sayed, Ibrahim El Tantawy, Wietrzyk, Joanna, Inokuchi, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600460/
https://www.ncbi.nlm.nih.gov/pubmed/31195640
http://dx.doi.org/10.3390/molecules24112121
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author Wang, Ning
Świtalska, Marta
Wang, Li
Shaban, Elkhabiry
Hossain, Md Imran
El Sayed, Ibrahim El Tantawy
Wietrzyk, Joanna
Inokuchi, Tsutomu
author_facet Wang, Ning
Świtalska, Marta
Wang, Li
Shaban, Elkhabiry
Hossain, Md Imran
El Sayed, Ibrahim El Tantawy
Wietrzyk, Joanna
Inokuchi, Tsutomu
author_sort Wang, Ning
collection PubMed
description Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel.
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spelling pubmed-66004602019-07-16 Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity Wang, Ning Świtalska, Marta Wang, Li Shaban, Elkhabiry Hossain, Md Imran El Sayed, Ibrahim El Tantawy Wietrzyk, Joanna Inokuchi, Tsutomu Molecules Review Cryptolepine, neocryptolepine and isocryptolepine are naturally occurring indoloquinoline alkaloids with various spectrum of biological properties. Structural modification is an extremely effective means to improve their bioactivities. This review enumerates several neocryptolepine and isocryptolepine analogues with potent antiproliferative activity against MV4-11 (leukemia), A549 (lung cancer), HCT116 (colon cancer) cell lines in vitro. Its activity towards normal mouse fibroblasts BALB/3T3 was also evaluated. Furthermore, structure activity relationships (SAR) are briefly discussed. The anticancer screening of neocryptolepine derivatives was performed in order to determine their cytotoxic and growth inhibitory activities across the JFCR39 cancer cell line panel. MDPI 2019-06-05 /pmc/articles/PMC6600460/ /pubmed/31195640 http://dx.doi.org/10.3390/molecules24112121 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Ning
Świtalska, Marta
Wang, Li
Shaban, Elkhabiry
Hossain, Md Imran
El Sayed, Ibrahim El Tantawy
Wietrzyk, Joanna
Inokuchi, Tsutomu
Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
title Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
title_full Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
title_fullStr Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
title_full_unstemmed Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
title_short Structural Modifications of Nature-Inspired Indoloquinolines: A Mini Review of Their Potential Antiproliferative Activity
title_sort structural modifications of nature-inspired indoloquinolines: a mini review of their potential antiproliferative activity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600460/
https://www.ncbi.nlm.nih.gov/pubmed/31195640
http://dx.doi.org/10.3390/molecules24112121
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