Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor

The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the t...

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Detalles Bibliográficos
Autores principales: Bouffard, Elise, Mauriello Jimenez, Chiara, El Cheikh, Khaled, Maynadier, Marie, Basile, Ilaria, Raehm, Laurence, Nguyen, Christophe, Gary-Bobo, Magali, Garcia, Marcel, Durand, Jean-Olivier, Morère, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600508/
https://www.ncbi.nlm.nih.gov/pubmed/31181759
http://dx.doi.org/10.3390/ijms20112809
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author Bouffard, Elise
Mauriello Jimenez, Chiara
El Cheikh, Khaled
Maynadier, Marie
Basile, Ilaria
Raehm, Laurence
Nguyen, Christophe
Gary-Bobo, Magali
Garcia, Marcel
Durand, Jean-Olivier
Morère, Alain
author_facet Bouffard, Elise
Mauriello Jimenez, Chiara
El Cheikh, Khaled
Maynadier, Marie
Basile, Ilaria
Raehm, Laurence
Nguyen, Christophe
Gary-Bobo, Magali
Garcia, Marcel
Durand, Jean-Olivier
Morère, Alain
author_sort Bouffard, Elise
collection PubMed
description The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs.
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spelling pubmed-66005082019-07-16 Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor Bouffard, Elise Mauriello Jimenez, Chiara El Cheikh, Khaled Maynadier, Marie Basile, Ilaria Raehm, Laurence Nguyen, Christophe Gary-Bobo, Magali Garcia, Marcel Durand, Jean-Olivier Morère, Alain Int J Mol Sci Communication The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs. MDPI 2019-06-08 /pmc/articles/PMC6600508/ /pubmed/31181759 http://dx.doi.org/10.3390/ijms20112809 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Bouffard, Elise
Mauriello Jimenez, Chiara
El Cheikh, Khaled
Maynadier, Marie
Basile, Ilaria
Raehm, Laurence
Nguyen, Christophe
Gary-Bobo, Magali
Garcia, Marcel
Durand, Jean-Olivier
Morère, Alain
Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
title Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
title_full Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
title_fullStr Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
title_full_unstemmed Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
title_short Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor
title_sort efficient photodynamic therapy of prostate cancer cells through an improved targeting of the cation-independent mannose 6-phosphate receptor
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600508/
https://www.ncbi.nlm.nih.gov/pubmed/31181759
http://dx.doi.org/10.3390/ijms20112809
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