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A Practical and Total Synthesis of Pasireotide: Synthesis of Cyclic Hexapeptide via a Three-Component Condensation

Pasireotide is a multi-receptor ligand somatostatin analogue approved for medical treatment of Cushing’s disease and acromegaly. The liquid-phase total synthesis of pasireotide-a 18-membered cyclic hexapeptide-was achieved by the 3 + 2 + 1 strategy, and the Pro(1)-Phe(6) peptide bond was selected as...

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Detalles Bibliográficos
Autores principales:	Ma, Chunying, Chen, Miao, Chu, Weiming, Tao, Jiayi, Kong, Delong, Zhang, Mengmeng, Feng, Wenhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600510/ https://www.ncbi.nlm.nih.gov/pubmed/31212595 http://dx.doi.org/10.3390/molecules24112185

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