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Synthesis and Cytotoxicity of 7,9-O-Linked Macrocyclic C-Seco Taxoids
A series of novel 7,9-O-linked macrocyclic taxoids together with modification at the C2 position were synthesized, and their cytotoxicities against drug-sensitive and P-glycoprotein and βIII-tubulin overexpressed drug-resistant cancer cell lines were evaluated. It is demonstrated that C-seco taxoids...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600541/ https://www.ncbi.nlm.nih.gov/pubmed/31181726 http://dx.doi.org/10.3390/molecules24112161 |