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Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats

Age-ing is involved in gradual breakdown of biological structure and function of body organs. The heart represents the main organ responsible for pumping the main issues of life which involving oxygen, nutrients and bioactive molecules necessary for maintaining the body functions. The present study...

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Autor principal: AL-Gebaly, Asma S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600591/
https://www.ncbi.nlm.nih.gov/pubmed/31303824
http://dx.doi.org/10.1016/j.sjbs.2018.03.014
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author AL-Gebaly, Asma S.
author_facet AL-Gebaly, Asma S.
author_sort AL-Gebaly, Asma S.
collection PubMed
description Age-ing is involved in gradual breakdown of biological structure and function of body organs. The heart represents the main organ responsible for pumping the main issues of life which involving oxygen, nutrients and bioactive molecules necessary for maintaining the body functions. The present study has been conducted to assess the anti-aging properties of whey syrup collected from fermented milk in 4, 18 and 30-months-old rats. The histopathological and histochemical changes of carbohydrates and proteins were investigated. Immunohistochemical expression of smooth muscle actin and P53 was performed to assess the function of cardiomyocytes. Furthermore, Annexin v and biochemical changes of different cardio-biomarkers were carried out to evaluate the effects of aging. The present result of 30 months-old rats revealed myocardial infarction assessed by widening of myocardial fibers, diffused with numerous blood capillaries and dense leukocytic infiltration. The assessed biochemical markers confirmed myocardial damage. Whey supplementation improved the myocardial structure, but less improvement was observed for the 30-months-old rats. The author recommended supplementation with whey is beneficial in giving a body the demand for amino acids and minerals essential for supporting the myocardium and also provides protection against age-ing.
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spelling pubmed-66005912019-07-12 Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats AL-Gebaly, Asma S. Saudi J Biol Sci Article Age-ing is involved in gradual breakdown of biological structure and function of body organs. The heart represents the main organ responsible for pumping the main issues of life which involving oxygen, nutrients and bioactive molecules necessary for maintaining the body functions. The present study has been conducted to assess the anti-aging properties of whey syrup collected from fermented milk in 4, 18 and 30-months-old rats. The histopathological and histochemical changes of carbohydrates and proteins were investigated. Immunohistochemical expression of smooth muscle actin and P53 was performed to assess the function of cardiomyocytes. Furthermore, Annexin v and biochemical changes of different cardio-biomarkers were carried out to evaluate the effects of aging. The present result of 30 months-old rats revealed myocardial infarction assessed by widening of myocardial fibers, diffused with numerous blood capillaries and dense leukocytic infiltration. The assessed biochemical markers confirmed myocardial damage. Whey supplementation improved the myocardial structure, but less improvement was observed for the 30-months-old rats. The author recommended supplementation with whey is beneficial in giving a body the demand for amino acids and minerals essential for supporting the myocardium and also provides protection against age-ing. Elsevier 2019-07 2018-03-27 /pmc/articles/PMC6600591/ /pubmed/31303824 http://dx.doi.org/10.1016/j.sjbs.2018.03.014 Text en © 2018 Production and hosting by Elsevier B.V. on behalf of King Saud University. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
AL-Gebaly, Asma S.
Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
title Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
title_full Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
title_fullStr Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
title_full_unstemmed Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
title_short Ameliorating role of whey syrup against ageing-related damage of myocardial muscle of Wistar Albino rats
title_sort ameliorating role of whey syrup against ageing-related damage of myocardial muscle of wistar albino rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600591/
https://www.ncbi.nlm.nih.gov/pubmed/31303824
http://dx.doi.org/10.1016/j.sjbs.2018.03.014
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