Design and Synthesis of Indoleamine 2,3-Dioxygenase 1 Inhibitors and Evaluation of Their Use as Anti-Tumor Agents

Indoleamine 2,3-dioxygenase (IDO) 1 is the key enzyme for regulating tryptophan metabolism and is an important target for interrupting tumor immune escape. In this study, we designed four series of compounds as potential IDO1 inhibitors by attaching various fragments or ligands to indole or phenylim...

Descripción completa

Detalles Bibliográficos
Autores principales: Wen, Hui, Liu, Yuke, Wang, Shufang, Wang, Ting, Zhang, Gang, Chen, Xiaoguang, Li, Yan, Cui, Huaqing, Lai, Fangfang, Sheng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600671/
https://www.ncbi.nlm.nih.gov/pubmed/31195673
http://dx.doi.org/10.3390/molecules24112124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600671/
https://www.ncbi.nlm.nih.gov/pubmed/31195673
http://dx.doi.org/10.3390/molecules24112124

Ejemplares similares