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Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India

Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate and emerged as an important contributor towards the difficult to treat BJI. Currently available anti...

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Autores principales: Prabhoo, Ram, Chaddha, Ram, Iyer, Rajagopalan, Mehra, Apurv, Ahdal, Jaishid, Jain, Rishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications, Pavia, Italy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600845/
https://www.ncbi.nlm.nih.gov/pubmed/31312419
http://dx.doi.org/10.4081/or.2019.8070
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author Prabhoo, Ram
Chaddha, Ram
Iyer, Rajagopalan
Mehra, Apurv
Ahdal, Jaishid
Jain, Rishi
author_facet Prabhoo, Ram
Chaddha, Ram
Iyer, Rajagopalan
Mehra, Apurv
Ahdal, Jaishid
Jain, Rishi
author_sort Prabhoo, Ram
collection PubMed
description Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate and emerged as an important contributor towards the difficult to treat BJI. Currently available anti-MRSA agents have their own limitations with regards to reduced susceptibility as well as safety and tolerability. Furthermore, biofilms over the prosthesis with invariably multi-drug resistant strains leads to complex treatment processes. This necessitates the need to develop and screen new antibiotics against MRSA that can easily penetrate the deep pockets of infection and take care of the challenges discussed. This review aims to discuss on MRSA infection in bone and joint infection, current antibiotic regimen, its associated limitations, and finally, the need to develop new antibiotic therapy for effective management of patients with BJI.
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spelling pubmed-66008452019-07-16 Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India Prabhoo, Ram Chaddha, Ram Iyer, Rajagopalan Mehra, Apurv Ahdal, Jaishid Jain, Rishi Orthop Rev (Pavia) Review Staphylococcus aureus is the most common pathogen causing bone and joint infections (BJI). In India, prevalence of Methicillin resistant Staphylococcus aureus (MRSA) is increasing at an alarming rate and emerged as an important contributor towards the difficult to treat BJI. Currently available anti-MRSA agents have their own limitations with regards to reduced susceptibility as well as safety and tolerability. Furthermore, biofilms over the prosthesis with invariably multi-drug resistant strains leads to complex treatment processes. This necessitates the need to develop and screen new antibiotics against MRSA that can easily penetrate the deep pockets of infection and take care of the challenges discussed. This review aims to discuss on MRSA infection in bone and joint infection, current antibiotic regimen, its associated limitations, and finally, the need to develop new antibiotic therapy for effective management of patients with BJI. PAGEPress Publications, Pavia, Italy 2019-06-20 /pmc/articles/PMC6600845/ /pubmed/31312419 http://dx.doi.org/10.4081/or.2019.8070 Text en ©Copyright R. Prabhoo et al., 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Prabhoo, Ram
Chaddha, Ram
Iyer, Rajagopalan
Mehra, Apurv
Ahdal, Jaishid
Jain, Rishi
Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India
title Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India
title_full Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India
title_fullStr Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India
title_full_unstemmed Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India
title_short Overview of methicillin resistant Staphylococcus aureus mediated bone and joint infections in India
title_sort overview of methicillin resistant staphylococcus aureus mediated bone and joint infections in india
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600845/
https://www.ncbi.nlm.nih.gov/pubmed/31312419
http://dx.doi.org/10.4081/or.2019.8070
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