Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs

Abdominal aortic aneurysm (AAA) remains the second most frequent vascular disease with high mortality but has no approved medical therapy. We investigated the direct role of apelin (APLN) in AAA and identified a unique approach to enhance APLN action as a therapeutic intervention for this disease. L...

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Detalles Bibliográficos
Autores principales: Wang, Wang, Shen, Mengcheng, Fischer, Conrad, Basu, Ratnadeep, Hazra, Saugata, Couvineau, Pierre, Paul, Manish, Wang, Faqi, Toth, Sandra, Mix, Doran S., Poglitsch, Marko, Gerard, Norma P., Bouvier, Michel, Vederas, John C., Penninger, Josef M., Kassiri, Zamaneh, Oudit, Gavin Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6600956/
https://www.ncbi.nlm.nih.gov/pubmed/31189595
http://dx.doi.org/10.1073/pnas.1900152116

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