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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells

Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients; however, some patients exhibit little or no nu...

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Detalles Bibliográficos
Autores principales:	Morgan, Rhys G., Ridsdale, Jenna, Payne, Megan, Heesom, Kate J., Wilson, Marieangela C., Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C., Blair, Allison, Waterman, Marian L., Tonks, Alex, Darley, Richard L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601079/ https://www.ncbi.nlm.nih.gov/pubmed/30630973 http://dx.doi.org/10.3324/haematol.2018.202846

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