Cargando…

Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway

Adriamycin (Adr) is a cytotoxic anthracycline agent that is utilized to manage many types of tumors, but its clinical use is undesirable due to severe cardiotoxicity. The present study aimed to investigate the cardioprotective effect of Achillea fragrantissima (A. fragrantissima) against Adr-induced...

Descripción completa

Detalles Bibliográficos
Autores principales: Hijazi, Maha A., Jambi, Hanan A., Aljehany, Buthaina M., Althaiban, Maha A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601502/
https://www.ncbi.nlm.nih.gov/pubmed/31317032
http://dx.doi.org/10.1155/2019/5269074
_version_ 1783431303251623936
author Hijazi, Maha A.
Jambi, Hanan A.
Aljehany, Buthaina M.
Althaiban, Maha A.
author_facet Hijazi, Maha A.
Jambi, Hanan A.
Aljehany, Buthaina M.
Althaiban, Maha A.
author_sort Hijazi, Maha A.
collection PubMed
description Adriamycin (Adr) is a cytotoxic anthracycline agent that is utilized to manage many types of tumors, but its clinical use is undesirable due to severe cardiotoxicity. The present study aimed to investigate the cardioprotective effect of Achillea fragrantissima (A. fragrantissima) against Adr-induced cardiotoxicity through the antioxidant and anti-inflammatory metabolic pathways. A single dose of Adr was injected in rats to induce cardiotoxicity. Rats are divided into 5 groups, control, A. fragrantissima 800, Adr, A. fragrantissima 400 + Adr, and A. fragrantissima 800 + Adr. 72 h after Adr administration, electrocardiographic (ECG) study was performed for all rats. Serum and hearts were then collected for biochemical and histopathological studies. A. fragrantissima ameliorated Adr-induced ST-segment elevation. It reduced Adr-induced elevation in lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), thiobarbituric acid reactive substance (TBARS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6. It also protected against Adr-induced histopathological changes. Pretreatment with the extract increased heart tissue contents of glutathione peroxidase (GSH-PX) and reduced glutathione (GSH). Phytochemical analysis of the extract revealed that it is rich in phenolic and flavonoid active constituents. The results of this study revealed that A. fragrantissima extract ameliorates Adr-induced cardiotoxicity via an antioxidant and anti-inflammatory mechanisms. Further studies are warranted in order to recognize the precise active constituents of this natural extract which are responsible for the antioxidant and anti-inflammatory actions.
format Online
Article
Text
id pubmed-6601502
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-66015022019-07-17 Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway Hijazi, Maha A. Jambi, Hanan A. Aljehany, Buthaina M. Althaiban, Maha A. Biomed Res Int Research Article Adriamycin (Adr) is a cytotoxic anthracycline agent that is utilized to manage many types of tumors, but its clinical use is undesirable due to severe cardiotoxicity. The present study aimed to investigate the cardioprotective effect of Achillea fragrantissima (A. fragrantissima) against Adr-induced cardiotoxicity through the antioxidant and anti-inflammatory metabolic pathways. A single dose of Adr was injected in rats to induce cardiotoxicity. Rats are divided into 5 groups, control, A. fragrantissima 800, Adr, A. fragrantissima 400 + Adr, and A. fragrantissima 800 + Adr. 72 h after Adr administration, electrocardiographic (ECG) study was performed for all rats. Serum and hearts were then collected for biochemical and histopathological studies. A. fragrantissima ameliorated Adr-induced ST-segment elevation. It reduced Adr-induced elevation in lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), thiobarbituric acid reactive substance (TBARS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and IL-6. It also protected against Adr-induced histopathological changes. Pretreatment with the extract increased heart tissue contents of glutathione peroxidase (GSH-PX) and reduced glutathione (GSH). Phytochemical analysis of the extract revealed that it is rich in phenolic and flavonoid active constituents. The results of this study revealed that A. fragrantissima extract ameliorates Adr-induced cardiotoxicity via an antioxidant and anti-inflammatory mechanisms. Further studies are warranted in order to recognize the precise active constituents of this natural extract which are responsible for the antioxidant and anti-inflammatory actions. Hindawi 2019-06-17 /pmc/articles/PMC6601502/ /pubmed/31317032 http://dx.doi.org/10.1155/2019/5269074 Text en Copyright © 2019 Maha A. Hijazi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hijazi, Maha A.
Jambi, Hanan A.
Aljehany, Buthaina M.
Althaiban, Maha A.
Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
title Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
title_full Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
title_fullStr Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
title_full_unstemmed Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
title_short Potential Protective Effect of Achillea fragrantissima against Adriamycin-Induced Cardiotoxicity in Rats via an Antioxidant and Anti-Inflammatory Pathway
title_sort potential protective effect of achillea fragrantissima against adriamycin-induced cardiotoxicity in rats via an antioxidant and anti-inflammatory pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601502/
https://www.ncbi.nlm.nih.gov/pubmed/31317032
http://dx.doi.org/10.1155/2019/5269074
work_keys_str_mv AT hijazimahaa potentialprotectiveeffectofachilleafragrantissimaagainstadriamycininducedcardiotoxicityinratsviaanantioxidantandantiinflammatorypathway
AT jambihanana potentialprotectiveeffectofachilleafragrantissimaagainstadriamycininducedcardiotoxicityinratsviaanantioxidantandantiinflammatorypathway
AT aljehanybuthainam potentialprotectiveeffectofachilleafragrantissimaagainstadriamycininducedcardiotoxicityinratsviaanantioxidantandantiinflammatorypathway
AT althaibanmahaa potentialprotectiveeffectofachilleafragrantissimaagainstadriamycininducedcardiotoxicityinratsviaanantioxidantandantiinflammatorypathway