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Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine
Cholelithiasis is a major public health concern that necessitates highly effective, feasible, and recurrence-preventing therapies. Currently available surgical treatments and medications cannot effectively avoid the recurrence of cholelithiasis. Hence, several Chinese herbal compounds (CHCs) are con...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601506/ https://www.ncbi.nlm.nih.gov/pubmed/31316569 http://dx.doi.org/10.1155/2019/2536452 |
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author | Chen, Qiliang Zhang, Yuanyuan Li, Shunan Chen, Shujiao Lin, Xuejuan Li, Candong Asakawa, Tetsuya |
author_facet | Chen, Qiliang Zhang, Yuanyuan Li, Shunan Chen, Shujiao Lin, Xuejuan Li, Candong Asakawa, Tetsuya |
author_sort | Chen, Qiliang |
collection | PubMed |
description | Cholelithiasis is a major public health concern that necessitates highly effective, feasible, and recurrence-preventing therapies. Currently available surgical treatments and medications cannot effectively avoid the recurrence of cholelithiasis. Hence, several Chinese herbal compounds (CHCs) are considered for the treatment of cholelithiasis, considering that they can effectively discharge gallstones and prevent the recurrence of such condition. In the present narrative review, we aim to summarize the underlying mechanisms of currently used CHCs in the treatment of cholelithiasis and to describe the current situation of traditional Chinese medicine (TCM) use for cholelithiasis. Several commonly used CHCs were used to illustrate these issues. We found that the mechanisms underlying the CHC treatments rely on the amelioration of the biliary dynamics factors, maintenance and protection of the liver function, reduction of the cholesterol and bilirubin levels, and regulation of the inflammatory reactions. CHCs as treatments based on TCM can ameliorate the overall bodily function, thereby preventing the recurrence of cholelithiasis. Appropriate application of CHCs would be beneficial for patients and clinicians, although the safety and efficacy of CHCs need further verification. |
format | Online Article Text |
id | pubmed-6601506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-66015062019-07-17 Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine Chen, Qiliang Zhang, Yuanyuan Li, Shunan Chen, Shujiao Lin, Xuejuan Li, Candong Asakawa, Tetsuya Evid Based Complement Alternat Med Review Article Cholelithiasis is a major public health concern that necessitates highly effective, feasible, and recurrence-preventing therapies. Currently available surgical treatments and medications cannot effectively avoid the recurrence of cholelithiasis. Hence, several Chinese herbal compounds (CHCs) are considered for the treatment of cholelithiasis, considering that they can effectively discharge gallstones and prevent the recurrence of such condition. In the present narrative review, we aim to summarize the underlying mechanisms of currently used CHCs in the treatment of cholelithiasis and to describe the current situation of traditional Chinese medicine (TCM) use for cholelithiasis. Several commonly used CHCs were used to illustrate these issues. We found that the mechanisms underlying the CHC treatments rely on the amelioration of the biliary dynamics factors, maintenance and protection of the liver function, reduction of the cholesterol and bilirubin levels, and regulation of the inflammatory reactions. CHCs as treatments based on TCM can ameliorate the overall bodily function, thereby preventing the recurrence of cholelithiasis. Appropriate application of CHCs would be beneficial for patients and clinicians, although the safety and efficacy of CHCs need further verification. Hindawi 2019-06-17 /pmc/articles/PMC6601506/ /pubmed/31316569 http://dx.doi.org/10.1155/2019/2536452 Text en Copyright © 2019 Qiliang Chen et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Chen, Qiliang Zhang, Yuanyuan Li, Shunan Chen, Shujiao Lin, Xuejuan Li, Candong Asakawa, Tetsuya Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine |
title | Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine |
title_full | Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine |
title_fullStr | Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine |
title_full_unstemmed | Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine |
title_short | Mechanisms Underlying the Prevention and Treatment of Cholelithiasis Using Traditional Chinese Medicine |
title_sort | mechanisms underlying the prevention and treatment of cholelithiasis using traditional chinese medicine |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601506/ https://www.ncbi.nlm.nih.gov/pubmed/31316569 http://dx.doi.org/10.1155/2019/2536452 |
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