Ribosome queuing enables non-AUG translation to be resistant to multiple protein synthesis inhibitors

Aberrant translation initiation at non-AUG start codons is associated with multiple cancers and neurodegenerative diseases. Nevertheless, how non-AUG translation may be regulated differently from canonical translation is poorly understood. Here, we used start codon-specific reporters and ribosome pr...

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Detalles Bibliográficos
Autores principales: Kearse, Michael G., Goldman, Daniel H., Choi, Jiou, Nwaezeapu, Chike, Liang, Dongming, Green, Katelyn M., Goldstrohm, Aaron C., Todd, Peter K., Green, Rachel, Wilusz, Jeremy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601509/
https://www.ncbi.nlm.nih.gov/pubmed/31171704
http://dx.doi.org/10.1101/gad.324715.119

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