A comprehensive search of functional sequence space using large mammalian display libraries created by gene editing

The construction of large libraries in mammalian cells allows the direct screening of millions of molecular variants for binding properties in a cell type relevant for screening or production. We have created mammalian cell libraries of up to 10 million clones displaying a repertoire of IgG-formatte...

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Detalles Bibliográficos
Autores principales: Parthiban, Kothai, Perera, Rajika L., Sattar, Maheen, Huang, Yanchao, Mayle, Sophie, Masters, Edward, Griffiths, Daniel, Surade, Sachin, Leah, Rachael, Dyson, Michael R., McCafferty, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601556/
https://www.ncbi.nlm.nih.gov/pubmed/31107136
http://dx.doi.org/10.1080/19420862.2019.1618673

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601556/
https://www.ncbi.nlm.nih.gov/pubmed/31107136
http://dx.doi.org/10.1080/19420862.2019.1618673

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