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Attenuated glutamine synthetase as a selection marker in CHO cells to efficiently isolate highly productive stable cells for the production of antibodies and other biologics

Chinese hamster ovary (CHO) cells are the biopharmaceutical industry’s primary means of manufacturing therapeutic proteins, including monoclonal antibodies. The major challenge in cell line development for the production of recombinant biopharmaceuticals lies in generating and isolating rare high-pr...

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Detalles Bibliográficos
Autores principales:	Lin, Pao-Chun, Chan, Kah Fai, Kiess, Irene A., Tan, Joselyn, Shahreel, Wahyu, Wong, Sze-Yue, Song, Zhiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601560/ https://www.ncbi.nlm.nih.gov/pubmed/31043114 http://dx.doi.org/10.1080/19420862.2019.1612690

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