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Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk factors account for differences in pancreatic...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601579/ https://www.ncbi.nlm.nih.gov/pubmed/31066497 http://dx.doi.org/10.1002/cam4.2209 |
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author | Huang, Brian Z. Stram, Daniel O. Le Marchand, Loic Haiman, Christopher A. Wilkens, Lynne R. Pandol, Stephen J. Zhang, Zuo‐Feng Monroe, Kristine R. Setiawan, Veronica Wendy |
author_facet | Huang, Brian Z. Stram, Daniel O. Le Marchand, Loic Haiman, Christopher A. Wilkens, Lynne R. Pandol, Stephen J. Zhang, Zuo‐Feng Monroe, Kristine R. Setiawan, Veronica Wendy |
author_sort | Huang, Brian Z. |
collection | PubMed |
description | While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk factors account for differences in pancreatic cancer risk among African Americans, Native Hawaiians, Japanese Americans, Latino Americans, and European Americans in the Multiethnic Cohort Study. Risk factor data were obtained from the baseline questionnaire. Cox regression was used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for pancreatic cancer associated with risk factors and ethnicity. During an average 16.9‐year follow‐up, 1,532 incident pancreatic cancer cases were identified among 184,559 at‐risk participants. Family history of pancreatic cancer (RR 1.97, 95% CI 1.50‐2.58), diabetes (RR 1.32, 95% CI 1.14‐1.54), body mass index ≥30 kg/m(2) (RR 1.25, 95% CI 1.08‐1.46), current smoking (<20 pack‐years RR 1.43, 95% CI 1.19‐1.73; ≥20 pack‐years RR 1.76, 95% CI 1.46‐2.12), and red meat intake (RR 1.17, 95% CI 1.00‐1.36) were associated with pancreatic cancer. After adjustment for these risk factors, Native Hawaiians (RR 1.60, 95% CI 1.30‐1.98), Japanese Americans (RR 1.33, 95% CI 1.15‐1.54), and African Americans (RR 1.20, 95% CI 1.01‐1.42), but not Latino Americans (RR 0.90, 95% CI 0.76‐1.07), had a higher risk of pancreatic cancer compared to European Americans. Interethnic differences in pancreatic cancer risk are not fully explained by differences in the distribution of known risk factors. The greater risks in Native Hawaiians and Japanese Americans are new findings and elucidating the causes of these high rates may improve our understanding and prevention of pancreatic cancer. |
format | Online Article Text |
id | pubmed-6601579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-66015792019-07-22 Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort Huang, Brian Z. Stram, Daniel O. Le Marchand, Loic Haiman, Christopher A. Wilkens, Lynne R. Pandol, Stephen J. Zhang, Zuo‐Feng Monroe, Kristine R. Setiawan, Veronica Wendy Cancer Med Cancer Prevention While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk factors account for differences in pancreatic cancer risk among African Americans, Native Hawaiians, Japanese Americans, Latino Americans, and European Americans in the Multiethnic Cohort Study. Risk factor data were obtained from the baseline questionnaire. Cox regression was used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for pancreatic cancer associated with risk factors and ethnicity. During an average 16.9‐year follow‐up, 1,532 incident pancreatic cancer cases were identified among 184,559 at‐risk participants. Family history of pancreatic cancer (RR 1.97, 95% CI 1.50‐2.58), diabetes (RR 1.32, 95% CI 1.14‐1.54), body mass index ≥30 kg/m(2) (RR 1.25, 95% CI 1.08‐1.46), current smoking (<20 pack‐years RR 1.43, 95% CI 1.19‐1.73; ≥20 pack‐years RR 1.76, 95% CI 1.46‐2.12), and red meat intake (RR 1.17, 95% CI 1.00‐1.36) were associated with pancreatic cancer. After adjustment for these risk factors, Native Hawaiians (RR 1.60, 95% CI 1.30‐1.98), Japanese Americans (RR 1.33, 95% CI 1.15‐1.54), and African Americans (RR 1.20, 95% CI 1.01‐1.42), but not Latino Americans (RR 0.90, 95% CI 0.76‐1.07), had a higher risk of pancreatic cancer compared to European Americans. Interethnic differences in pancreatic cancer risk are not fully explained by differences in the distribution of known risk factors. The greater risks in Native Hawaiians and Japanese Americans are new findings and elucidating the causes of these high rates may improve our understanding and prevention of pancreatic cancer. John Wiley and Sons Inc. 2019-05-08 /pmc/articles/PMC6601579/ /pubmed/31066497 http://dx.doi.org/10.1002/cam4.2209 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cancer Prevention Huang, Brian Z. Stram, Daniel O. Le Marchand, Loic Haiman, Christopher A. Wilkens, Lynne R. Pandol, Stephen J. Zhang, Zuo‐Feng Monroe, Kristine R. Setiawan, Veronica Wendy Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort |
title | Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort |
title_full | Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort |
title_fullStr | Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort |
title_full_unstemmed | Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort |
title_short | Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort |
title_sort | interethnic differences in pancreatic cancer incidence and risk factors: the multiethnic cohort |
topic | Cancer Prevention |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601579/ https://www.ncbi.nlm.nih.gov/pubmed/31066497 http://dx.doi.org/10.1002/cam4.2209 |
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