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Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort

While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk factors account for differences in pancreatic...

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Autores principales: Huang, Brian Z., Stram, Daniel O., Le Marchand, Loic, Haiman, Christopher A., Wilkens, Lynne R., Pandol, Stephen J., Zhang, Zuo‐Feng, Monroe, Kristine R., Setiawan, Veronica Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601579/
https://www.ncbi.nlm.nih.gov/pubmed/31066497
http://dx.doi.org/10.1002/cam4.2209
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author Huang, Brian Z.
Stram, Daniel O.
Le Marchand, Loic
Haiman, Christopher A.
Wilkens, Lynne R.
Pandol, Stephen J.
Zhang, Zuo‐Feng
Monroe, Kristine R.
Setiawan, Veronica Wendy
author_facet Huang, Brian Z.
Stram, Daniel O.
Le Marchand, Loic
Haiman, Christopher A.
Wilkens, Lynne R.
Pandol, Stephen J.
Zhang, Zuo‐Feng
Monroe, Kristine R.
Setiawan, Veronica Wendy
author_sort Huang, Brian Z.
collection PubMed
description While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk factors account for differences in pancreatic cancer risk among African Americans, Native Hawaiians, Japanese Americans, Latino Americans, and European Americans in the Multiethnic Cohort Study. Risk factor data were obtained from the baseline questionnaire. Cox regression was used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for pancreatic cancer associated with risk factors and ethnicity. During an average 16.9‐year follow‐up, 1,532 incident pancreatic cancer cases were identified among 184,559 at‐risk participants. Family history of pancreatic cancer (RR 1.97, 95% CI 1.50‐2.58), diabetes (RR 1.32, 95% CI 1.14‐1.54), body mass index ≥30 kg/m(2) (RR 1.25, 95% CI 1.08‐1.46), current smoking (<20 pack‐years RR 1.43, 95% CI 1.19‐1.73; ≥20 pack‐years RR 1.76, 95% CI 1.46‐2.12), and red meat intake (RR 1.17, 95% CI 1.00‐1.36) were associated with pancreatic cancer. After adjustment for these risk factors, Native Hawaiians (RR 1.60, 95% CI 1.30‐1.98), Japanese Americans (RR 1.33, 95% CI 1.15‐1.54), and African Americans (RR 1.20, 95% CI 1.01‐1.42), but not Latino Americans (RR 0.90, 95% CI 0.76‐1.07), had a higher risk of pancreatic cancer compared to European Americans. Interethnic differences in pancreatic cancer risk are not fully explained by differences in the distribution of known risk factors. The greater risks in Native Hawaiians and Japanese Americans are new findings and elucidating the causes of these high rates may improve our understanding and prevention of pancreatic cancer.
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spelling pubmed-66015792019-07-22 Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort Huang, Brian Z. Stram, Daniel O. Le Marchand, Loic Haiman, Christopher A. Wilkens, Lynne R. Pandol, Stephen J. Zhang, Zuo‐Feng Monroe, Kristine R. Setiawan, Veronica Wendy Cancer Med Cancer Prevention While disparity in pancreatic cancer incidence between blacks and whites has been observed, few studies have examined disparity in other ethnic minorities. We evaluated variations in pancreatic cancer incidence and assessed the extent to which known risk factors account for differences in pancreatic cancer risk among African Americans, Native Hawaiians, Japanese Americans, Latino Americans, and European Americans in the Multiethnic Cohort Study. Risk factor data were obtained from the baseline questionnaire. Cox regression was used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for pancreatic cancer associated with risk factors and ethnicity. During an average 16.9‐year follow‐up, 1,532 incident pancreatic cancer cases were identified among 184,559 at‐risk participants. Family history of pancreatic cancer (RR 1.97, 95% CI 1.50‐2.58), diabetes (RR 1.32, 95% CI 1.14‐1.54), body mass index ≥30 kg/m(2) (RR 1.25, 95% CI 1.08‐1.46), current smoking (<20 pack‐years RR 1.43, 95% CI 1.19‐1.73; ≥20 pack‐years RR 1.76, 95% CI 1.46‐2.12), and red meat intake (RR 1.17, 95% CI 1.00‐1.36) were associated with pancreatic cancer. After adjustment for these risk factors, Native Hawaiians (RR 1.60, 95% CI 1.30‐1.98), Japanese Americans (RR 1.33, 95% CI 1.15‐1.54), and African Americans (RR 1.20, 95% CI 1.01‐1.42), but not Latino Americans (RR 0.90, 95% CI 0.76‐1.07), had a higher risk of pancreatic cancer compared to European Americans. Interethnic differences in pancreatic cancer risk are not fully explained by differences in the distribution of known risk factors. The greater risks in Native Hawaiians and Japanese Americans are new findings and elucidating the causes of these high rates may improve our understanding and prevention of pancreatic cancer. John Wiley and Sons Inc. 2019-05-08 /pmc/articles/PMC6601579/ /pubmed/31066497 http://dx.doi.org/10.1002/cam4.2209 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Huang, Brian Z.
Stram, Daniel O.
Le Marchand, Loic
Haiman, Christopher A.
Wilkens, Lynne R.
Pandol, Stephen J.
Zhang, Zuo‐Feng
Monroe, Kristine R.
Setiawan, Veronica Wendy
Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
title Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
title_full Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
title_fullStr Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
title_full_unstemmed Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
title_short Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort
title_sort interethnic differences in pancreatic cancer incidence and risk factors: the multiethnic cohort
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601579/
https://www.ncbi.nlm.nih.gov/pubmed/31066497
http://dx.doi.org/10.1002/cam4.2209
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