A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population

Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K‐AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathwa...

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Detalles Bibliográficos
Autores principales: Zhu, Ying, Ke, Juntao, Gong, Yajie, Yang, Yang, Peng, Xiating, Tian, Jianbo, Zou, Danyi, Yang, Nan, Wang, Xiaoyang, Mei, Shufang, Rao, Meilin, Ying, Pingting, Deng, Yao, Wang, Haoxue, Zhang, Hongli, Li, Bin, Wan, Hao, Li, Yue, Niu, Siyuan, Cai, Yimin, Zhang, Ming, Lu, Zequn, Zhong, Rong, Miao, Xiaoping, Chang, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Prevention
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601582/
https://www.ncbi.nlm.nih.gov/pubmed/31059194
http://dx.doi.org/10.1002/cam4.2228
Descripción
Sumario:Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K‐AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathway. In order to investigate the associations between genetic variations in that pathway and pancreatic cancer prognosis, we conducted a two‐stage survival analysis in a total of 547 Chinese pancreatic cancer patients. Consequently, a variant, rs13167294 A>C in PIK3R1, was significantly associated with poor survival in both stages and with hazard ratio being 1.32 (95% CI = 1.13‐1.56, P = 0.0007) in the combined analysis. Function annotation and prediction suggested that genetic variants in this locus might affect overall survival of pancreatic cancer patients by regulating PIK3R1 expression.

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