A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population

Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K‐AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathwa...

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Autores principales: Zhu, Ying, Ke, Juntao, Gong, Yajie, Yang, Yang, Peng, Xiating, Tian, Jianbo, Zou, Danyi, Yang, Nan, Wang, Xiaoyang, Mei, Shufang, Rao, Meilin, Ying, Pingting, Deng, Yao, Wang, Haoxue, Zhang, Hongli, Li, Bin, Wan, Hao, Li, Yue, Niu, Siyuan, Cai, Yimin, Zhang, Ming, Lu, Zequn, Zhong, Rong, Miao, Xiaoping, Chang, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cancer Prevention
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601582/
https://www.ncbi.nlm.nih.gov/pubmed/31059194
http://dx.doi.org/10.1002/cam4.2228
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author Zhu, Ying
Ke, Juntao
Gong, Yajie
Yang, Yang
Peng, Xiating
Tian, Jianbo
Zou, Danyi
Yang, Nan
Wang, Xiaoyang
Mei, Shufang
Rao, Meilin
Ying, Pingting
Deng, Yao
Wang, Haoxue
Zhang, Hongli
Li, Bin
Wan, Hao
Li, Yue
Niu, Siyuan
Cai, Yimin
Zhang, Ming
Lu, Zequn
Zhong, Rong
Miao, Xiaoping
Chang, Jiang
author_facet Zhu, Ying
Ke, Juntao
Gong, Yajie
Yang, Yang
Peng, Xiating
Tian, Jianbo
Zou, Danyi
Yang, Nan
Wang, Xiaoyang
Mei, Shufang
Rao, Meilin
Ying, Pingting
Deng, Yao
Wang, Haoxue
Zhang, Hongli
Li, Bin
Wan, Hao
Li, Yue
Niu, Siyuan
Cai, Yimin
Zhang, Ming
Lu, Zequn
Zhong, Rong
Miao, Xiaoping
Chang, Jiang
author_sort Zhu, Ying
collection PubMed
description Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K‐AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathway. In order to investigate the associations between genetic variations in that pathway and pancreatic cancer prognosis, we conducted a two‐stage survival analysis in a total of 547 Chinese pancreatic cancer patients. Consequently, a variant, rs13167294 A>C in PIK3R1, was significantly associated with poor survival in both stages and with hazard ratio being 1.32 (95% CI = 1.13‐1.56, P = 0.0007) in the combined analysis. Function annotation and prediction suggested that genetic variants in this locus might affect overall survival of pancreatic cancer patients by regulating PIK3R1 expression.
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spelling pubmed-66015822019-07-22 A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population Zhu, Ying Ke, Juntao Gong, Yajie Yang, Yang Peng, Xiating Tian, Jianbo Zou, Danyi Yang, Nan Wang, Xiaoyang Mei, Shufang Rao, Meilin Ying, Pingting Deng, Yao Wang, Haoxue Zhang, Hongli Li, Bin Wan, Hao Li, Yue Niu, Siyuan Cai, Yimin Zhang, Ming Lu, Zequn Zhong, Rong Miao, Xiaoping Chang, Jiang Cancer Med Cancer Prevention Pancreatic cancer is one of the deadliest malignancies with few early detection tests or effective therapies. PI3K‐AKT signaling is recognized to modulate cancer progression. We previously identified that a genetic variant in PKN1 increased pancreatic cancer risk through the PKN1/FAK/PI3K/AKT pathway. In order to investigate the associations between genetic variations in that pathway and pancreatic cancer prognosis, we conducted a two‐stage survival analysis in a total of 547 Chinese pancreatic cancer patients. Consequently, a variant, rs13167294 A>C in PIK3R1, was significantly associated with poor survival in both stages and with hazard ratio being 1.32 (95% CI = 1.13‐1.56, P = 0.0007) in the combined analysis. Function annotation and prediction suggested that genetic variants in this locus might affect overall survival of pancreatic cancer patients by regulating PIK3R1 expression. John Wiley and Sons Inc. 2019-05-06 /pmc/articles/PMC6601582/ /pubmed/31059194 http://dx.doi.org/10.1002/cam4.2228 Text en © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Prevention
Zhu, Ying
Ke, Juntao
Gong, Yajie
Yang, Yang
Peng, Xiating
Tian, Jianbo
Zou, Danyi
Yang, Nan
Wang, Xiaoyang
Mei, Shufang
Rao, Meilin
Ying, Pingting
Deng, Yao
Wang, Haoxue
Zhang, Hongli
Li, Bin
Wan, Hao
Li, Yue
Niu, Siyuan
Cai, Yimin
Zhang, Ming
Lu, Zequn
Zhong, Rong
Miao, Xiaoping
Chang, Jiang
A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
title A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
title_full A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
title_fullStr A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
title_full_unstemmed A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
title_short A genetic variant in PIK3R1 is associated with pancreatic cancer survival in the Chinese population
title_sort genetic variant in pik3r1 is associated with pancreatic cancer survival in the chinese population
topic Cancer Prevention
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601582/
https://www.ncbi.nlm.nih.gov/pubmed/31059194
http://dx.doi.org/10.1002/cam4.2228
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