Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA-seq and flow cytometry to T cells, B cells, monocytes and fibroblasts from 51 samples of synovial tissue from patients with RA or ost...

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Detalles Bibliográficos
Autores principales: Zhang, Fan, Wei, Kevin, Slowikowski, Kamil, Fonseka, Chamith Y., Rao, Deepak A., Kelly, Stephen, Goodman, Susan M., Tabechian, Darren, Hughes, Laura B., Salomon-Escoto, Karen, Watts, Gerald F. M., Jonsson, Anna H., Rangel-Moreno, Javier, Pellett, Nida M., Rozo, Cristina, Apruzzese, William, Eisenhaure, Thomas M., Lieb, David J., Boyle, David L., Mandelin, Arthur M., Boyce, Brendan F., DiCarlo, Edward, Gravallese, Ellen M., Gregersen, Peter K., Moreland, Larry, Firestein, Gary S., Hacohen, Nir, Nusbaum, Chad, Lederer, James A., Perlman, Harris, Pitzalis, Costantino, Filer, Andrew, Holers, V. Michael, Bykerk, Vivian P., Donlin, Laura T., Anolik, Jennifer H., Brenner, Michael B., Raychaudhuri, Soumya, Albrecht, Jennifer, Bridges, S. Louis, Buckley, Christopher D., Buckner, Jane H., Dolan, James, Guthridge, Joel M., Gutierrez-Arcelus, Maria, Ivashkiv, Lionel B., James, Eddie A., James, Judith A., Keegan, Josh, Lee, Yvonne C., McGeachy, Mandy J., McNamara, Michael A., Mears, Joseph R., Mizoguchi, Fumitaka, Nguyen, Jennifer P., Noma, Akiko, Orange, Dana E., Rohani-Pichavant, Mina, Ritchlin, Christopher, Robinson, William H., Seshadri, Anupamaa, Sutherby, Danielle, Seifert, Jennifer, Turner, Jason D., Utz, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602051/
https://www.ncbi.nlm.nih.gov/pubmed/31061532
http://dx.doi.org/10.1038/s41590-019-0378-1

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