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First Clinical Application of Low-Cost OCT

PURPOSE: We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. METHODS: A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost,...

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Autores principales: Song, Ge, Chu, Kengyeh K., Kim, Sanghoon, Crose, Michael, Cox, Brian, Jelly, Evan T., Ulrich, J. Niklas, Wax, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602122/
https://www.ncbi.nlm.nih.gov/pubmed/31293815
http://dx.doi.org/10.1167/tvst.8.3.61
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author Song, Ge
Chu, Kengyeh K.
Kim, Sanghoon
Crose, Michael
Cox, Brian
Jelly, Evan T.
Ulrich, J. Niklas
Wax, Adam
author_facet Song, Ge
Chu, Kengyeh K.
Kim, Sanghoon
Crose, Michael
Cox, Brian
Jelly, Evan T.
Ulrich, J. Niklas
Wax, Adam
author_sort Song, Ge
collection PubMed
description PURPOSE: We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. METHODS: A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using both the low-cost OCT and a Heidelberg Engineering Spectralis OCT. Contrast-to-noise ratio (CNR) was measured from resulting images to determine system performance. RESULTS: The low-cost OCT system was successfully applied to clinical imaging of the retina. The system offers an axial resolution of 8.0 μm, a lateral resolution of 19.6 μm, and an imaging depth of 2.7 mm for a 6.6-mm field of view in the X and Y directions. Total cost is $5037, a significant size reduction compared to current commercial higher performance systems. Mean CNR value of low-cost OCT images is only 5.6% lower compared to the Heidelberg Spectralis. CONCLUSIONS: The images captured with the low-cost OCT were of adequate resolution and allowed for clinical diagnostics. It offers comparable performance as a retinal screening tool at a fraction of the cost of current commercial systems. TRANSLATIONAL RELEVANCE: Low-cost OCT has the potential to increase access to retinal imaging.
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spelling pubmed-66021222019-07-10 First Clinical Application of Low-Cost OCT Song, Ge Chu, Kengyeh K. Kim, Sanghoon Crose, Michael Cox, Brian Jelly, Evan T. Ulrich, J. Niklas Wax, Adam Transl Vis Sci Technol Articles PURPOSE: We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. METHODS: A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using both the low-cost OCT and a Heidelberg Engineering Spectralis OCT. Contrast-to-noise ratio (CNR) was measured from resulting images to determine system performance. RESULTS: The low-cost OCT system was successfully applied to clinical imaging of the retina. The system offers an axial resolution of 8.0 μm, a lateral resolution of 19.6 μm, and an imaging depth of 2.7 mm for a 6.6-mm field of view in the X and Y directions. Total cost is $5037, a significant size reduction compared to current commercial higher performance systems. Mean CNR value of low-cost OCT images is only 5.6% lower compared to the Heidelberg Spectralis. CONCLUSIONS: The images captured with the low-cost OCT were of adequate resolution and allowed for clinical diagnostics. It offers comparable performance as a retinal screening tool at a fraction of the cost of current commercial systems. TRANSLATIONAL RELEVANCE: Low-cost OCT has the potential to increase access to retinal imaging. The Association for Research in Vision and Ophthalmology 2019-06-28 /pmc/articles/PMC6602122/ /pubmed/31293815 http://dx.doi.org/10.1167/tvst.8.3.61 Text en Copyright 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Articles
Song, Ge
Chu, Kengyeh K.
Kim, Sanghoon
Crose, Michael
Cox, Brian
Jelly, Evan T.
Ulrich, J. Niklas
Wax, Adam
First Clinical Application of Low-Cost OCT
title First Clinical Application of Low-Cost OCT
title_full First Clinical Application of Low-Cost OCT
title_fullStr First Clinical Application of Low-Cost OCT
title_full_unstemmed First Clinical Application of Low-Cost OCT
title_short First Clinical Application of Low-Cost OCT
title_sort first clinical application of low-cost oct
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602122/
https://www.ncbi.nlm.nih.gov/pubmed/31293815
http://dx.doi.org/10.1167/tvst.8.3.61
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