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Cell-Based Screen Using Amyloid Mimic β23 Expression Identifies Peucedanocoumarin III as a Novel Inhibitor of α-Synuclein and Huntingtin Aggregates
Aggregates of disease-causing proteins dysregulate cellular functions, thereby causing neuronal cell loss in diverse neurodegenerative diseases. Although many in vitro or in vivo studies of protein aggregate inhibitors have been performed, a therapeutic strategy to control aggregate toxicity has not...
Autores principales: | Ham, Sangwoo, Kim, Hyojung, Hwang, Seojin, Kang, Hyunook, Yun, Seung Pil, Kim, Sangjune, Kim, Donghoon, Kwon, Hyun Sook, Lee, Yun-Song, Cho, MyoungLae, Shin, Heung-Mook, Choi, Heejung, Chung, Ka Young, Ko, Han Seok, Lee, Gum Hwa, Lee, Yunjong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602149/ https://www.ncbi.nlm.nih.gov/pubmed/31250621 http://dx.doi.org/10.14348/molcells.2019.0091 |
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