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Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. Chimeric mAb 2C7 (human immunoglobulin G1 [IgG1]...

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Detalles Bibliográficos
Autores principales:	Gulati, Sunita, Beurskens, Frank J., de Kreuk, Bart-Jan, Roza, Marcel, Zheng, Bo, DeOliveira, Rosane B., Shaughnessy, Jutamas, Nowak, Nancy A., Taylor, Ronald P., Botto, Marina, He, Xianbao, Ingalls, Robin R., Woodruff, Trent M., Song, Wen-Chao, Schuurman, Janine, Rice, Peter A., Ram, Sanjay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602280/ https://www.ncbi.nlm.nih.gov/pubmed/31216278 http://dx.doi.org/10.1371/journal.pbio.3000323

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