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Structural mechanism for guanylate-binding proteins (GBPs) targeting by the Shigella E3 ligase IpaH9.8

The guanylate-binding proteins (GBPs) belong to the dynamin superfamily of GTPases and function in cell-autonomous defense against intracellular pathogens. IpaH9.8, an E3 ligase from the pathogenic bacterium Shigella flexneri, ubiquitinates a subset of GBPs and leads to their proteasomal degradation...

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Detalles Bibliográficos
Autores principales:	Ji, Chenggong, Du, Shuo, Li, Peng, Zhu, Qinyu, Yang, Xiaoke, Long, Chunhong, Yu, Jin, Shao, Feng, Xiao, Junyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6602295/ https://www.ncbi.nlm.nih.gov/pubmed/31216343 http://dx.doi.org/10.1371/journal.ppat.1007876

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